Hypertension is a major contributing factor to cardiovascular disease and is a leading cause of death in the world. The association between hepatic enzymes and hypertension has been reported in limited studies and the findings are inconsistent; data from Bangladeshi adults are not available yet. This study was conducted to estimate the prevalence of elevated liver enzymes and evaluate the association of elevated liver enzymes with hypertension in Bangladeshi adults. In this cross-sectional study, 302 blood samples were collected from adult participants and analyzed the serum concentrations of alanine and aspartate aminotransferase (ALT, AST), alkaline phosphatase (ALP), and γ-glutamyltransferase (GGT) and other markers related to hypertension. Hypertension was defined as resting SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg. Associations between elevated liver enzymes and hypertension were evaluated by multinomial logistic regression. The mean concentrations of serum ALT, AST and GGT were significantly higher in the hypertensive group compared to the normotensive group (p < 0.01, p < 0.01 and p < 0.001, respectively). Overall, 49.2% of subjects in the hypertensive group and 38.1% of individuals in the normotensive group had at least one or more elevated liver enzymes. The prevalence of elevated ALT, AST, and GGT was significantly higher among participants in the hypertensive group compared to the normotensive group (p < 0.01, p < 0.01 and p < 0.001, respectively). An increasing trend for elevated liver enzymes was observed with increasing blood pressure. Serum ALT and GGT showed an independent relationship with hypertension. The prevalence of elevated liver enzymes was higher in hypertensive individuals. Increased serum ALT and GGT activities were positively associated with hypertension in Bangladeshi adults.

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血清肝酶与高血压之间的关联：孟加拉国成年人的横断面研究

高血压是导致心血管疾病的主要因素，也是世界上主要的死亡原因。在有限的研究中已经报道了肝酶与高血压之间的关联，并且发现不一致。尚无来自孟加拉国成年人的数据。进行这项研究是为了评估孟加拉国成年人肝酶升高的患病率，并评估肝酶升高与高血压的关系。在这项横断面研究中，从成年参与者中收集了302份血液样本，分析了血清丙氨酸和天冬氨酸转氨酶（ALT，AST），碱性磷酸酶（ALP）和γ-谷氨酰转移酶（GGT）的浓度以及其他与高血压相关的标志物。高血压定义为静息SBP≥140 mmHg和/或DBP≥90 mmHg。肝酶升高与高血压之间的相关性通过多项逻辑回归进行评估。与正常血压组相比，高血压组的血清ALT，AST和GGT的平均浓度显着更高（分别为p <0.01，p <0.01和p <0.001）。总体而言，高血压组中49.2％的受试者和血压正常组中38.1％的个体中至少有一种或多种肝酶升高。与正常血压组相比，高血压组参与者ALT，AST和GGT升高的发生率显着更高（分别为p <0.01，p <0.01和p <0.001）。随着血压升高，观察到肝酶升高的趋势。血清ALT和GGT与高血压无关。高血压患者肝酶升高的患病率较高。孟加拉成年人的血清ALT和GGT活性升高与高血压呈正相关。