Nowadays, screw feeders are popular equipment in the pharmaceutical industry. However, despite the increasing research in the last decade in the manufacturing of powder-based products, there is still a lack of knowledge on the physics governing the dynamic behavior of these systems. As a result, data-driven models have often been used to address process design, optimization, and control applications. In this paper, a methodology for the modeling of twin screw feeders has been suggested. A first order plus dead time model has been developed, where a hybrid mechanistic-empirical approach has been used. Different powders and two screw feeder geometries have been investigated. The model predictions are in good agreement with the experimental measurements when the 35 mm diameter screws are employed. When the 20 mm diameter screws are used, the validity range of the model is limited for the least cohesive powders, suggesting that their screw speed-dependent resistance to flow in small screws requires further investigations.

中文翻译：

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连续片剂制造双螺杆给料机建模的混合机械-经验方法

如今，螺旋给料机已成为制药行业中的热门设备。然而，尽管在过去的十年中在粉末基产品的制造方面进行了越来越多的研究，但是仍然缺乏有关控制这些系统的动态行为的物理学知识。结果，数据驱动的模型经常被用于解决过程设计，优化和控制应用程序。在本文中，提出了一种双螺杆给料机的建模方法。一阶加停滞时间模型已经开发，其中使用了混合的机械-经验方法。已经研究了不同的粉末和两种螺旋进料器的几何形状。当使用直径为35 mm的螺钉时，模型预测与实验测量结果非常吻合。使用20毫米直径的螺钉时，