Improving Ion Mobility Spectrometer Sensitivity through the Extended Field Switching Ion Shutter,Analytical Chemistry

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Improving Ion Mobility Spectrometer Sensitivity through the Extended Field Switching Ion Shutter
Analytical Chemistry ( IF 6.7 ) Pub Date : 2020-03-24 , DOI: 10.1021/acs.analchem.9b04259
Ansgar T. Kirk ₁ , Maximilian J. Kueddelsmann ₁ , Alexander Bohnhorst ₁ , Martin Lippmann ₁ , Stefan Zimmermann ₁

Affiliation

Field switching ion shutters allow generating short ion packets with high ion densities by first ionizing for several milliseconds in a field-free ionization region and then quickly pushing the entire ion population out into the drift region. Thus, they are an excellent choice for compact ion mobility spectrometers with both high resolving power and low limits of detection. Here, we present an improved setup, named the extended field switching ion shutter. By generating a second field-free region between the ionization region and the drift region, shielding of the ionization region is significantly improved, even when using grids with higher optical transparency to improve ion transmission into the drift region. Furthermore, it is shown that under certain conditions, ion transmission through multiple grids in series can even surpass transmission through a single grid of the same transparency. For the studied ions, the signal intensity at low concentrations increases by approximately a factor of 7 to 9 for protonated monomers, 10 to 14 for proton-bound dimers, and 25 for the proton-bound 1-octanol trimer compared to the classical field switching shutter. However, due to the nonlinear response for ions containing multiple analyte molecules, the limits of detection improve only by a factor of 3 to 4 for proton-bound dimers and 3 for the proton-bound 1-octanol trimer. Nevertheless, this still leads to single-digit ppt_v limits of detection for protonated monomers and hundred ppt_v limits of detection for proton-bound dimers measured for a series of ketones. However, for the most intense peaks such as the reactant ion peak, a significant loss of resolving power by a factor of up to 1.4 was observed due to Coulomb repulsion.

中文翻译：

通过扩展场切换离子快门提高离子迁移谱仪的灵敏度

场切换离子快门通过首先在无场电离区域中电离几毫秒，然后迅速将整个离子种群推入漂移区域，从而生成具有高离子密度的短离子包。因此，它们是具有高分辨能力和低检测限的紧凑型离子迁移谱仪的绝佳选择。在这里，我们提出一种改进的设置，称为扩展场切换离子快门。通过在电离区域和漂移区域之间生成第二无电场区域，即使使用具有更高光学透明性的栅格来改善离子向漂移区域的传输，电离区域的屏蔽也会得到显着改善。而且，表明在某些条件下，通过串联的多个栅格的离子传输甚至可以超过通过相同透明度的单个栅格的离子传输。对于被研究的离子，与经典的场切换相比，低浓度下的信号强度对于质子化的单体而言增加了大约7到9倍，对于与质子结合的二聚体为10至14倍，对于与质子结合的1-辛醇三聚体为25倍快门。但是，由于包含多个分析物分子的离子的非线性响应，质子结合的二聚体的检测限仅提高了3到4倍，质子结合的1-辛醇三聚体的检测限仅提高了3倍。然而，这仍然导致单位ppt 与传统的场切换百叶窗相比，质子结合的二聚体为10至14，质子结合的1-辛醇三聚体为25。但是，由于包含多个分析物分子的离子的非线性响应，质子结合的二聚体的检测限仅提高了3到4倍，质子结合的1-辛醇三聚体的检测限仅提高了3倍。然而，这仍然导致单位ppt 与传统的场切换百叶窗相比，质子结合的二聚体为10至14，质子结合的1-辛醇三聚体为25。但是，由于包含多个分析物分子的离子的非线性响应，质子结合的二聚体的检测限仅提高了3到4倍，质子结合的1-辛醇三聚体的检测限仅提高了3倍。然而，这仍然导致单位ppt_v质子化单体的检测限和100 ppt _v一系列酮测得的质子结合二聚体的检测限。但是，对于最强的峰（例如反应物离子峰），由于库仑排斥，观察到分辨力的显着降低，最高达1.4。

更新日期：2020-03-26

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