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Zinc, an unexpected integrator of metabolism?
Microbial Biotechnology ( IF 4.8 ) Pub Date : 2020-03-09 , DOI: 10.1111/1751-7915.13549
Antoine Danchin 1
Affiliation  

Even when they no longer require the presence of iron, cells use zinc as a divalent cation, involved in a large variety of catalytic and regulatory functions. This metal is so important that it appears that ribosomes are instrumental in its ultimate storage. Here, we summarize a detailed analysis which investigates the way the global cell metabolism is integrated by zinc. This integration results from the zinc‐dependent way in which the one‐carbon metabolism is always coupled to the translation process, not only via methionine and S‐adenosylmethionine, but via the complex set‐up of the modification of the position 34 of the anticodon of tRNAs.

中文翻译:


锌,意想不到的新陈代谢整合剂?



即使细胞不再需要铁的存在,它们也会使用锌作为二价阳离子,参与多种催化和调节功能。这种金属非常重要,核糖体似乎在其最终储存中发挥了重要作用。在这里,我们总结了一项详细的分析,研究锌如何整合整体细胞代谢的方式。这种整合源于锌依赖性方式,其中单碳代谢始终与翻译过程耦合,不仅通过甲硫氨酸和S-腺苷甲硫氨酸,而且通过反密码子 34 位修饰的复杂设置tRNA。
更新日期:2020-03-09
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