Noncovalent Chalcogen‐Bonding Catalysis Using ppm‐Level Catalyst Loading to Achieve Cyanosilylation of Ketones,Asian Journal of Organic Chemistry

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Noncovalent Chalcogen‐Bonding Catalysis Using ppm‐Level Catalyst Loading to Achieve Cyanosilylation of Ketones
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-23 , DOI: 10.1002/ajoc.202000127
Lintao Bao ₁ , Xiangjin Kong ₁ , Yao Wang ₁

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As noncovalent chalcogen‐bonding interaction is comparatively weak, it remains a true challenge to implement chalcogen‐bonding catalysis in an efficient manner. We herein show that a chalcogen‐bonding catalysis approach to cyanosilylation of a broad range of ketones can be achieved even using as low as parts per million (ppm) level catalyst loading while the reactions were completed within several minutes at room temperature. Considering the nature of weak noncovalent forces, this chalcogen‐bonding catalysis approach is remarkable as it can give up to 10⁶/h turnover frequency numbers.

中文翻译：

非共价硫属元素键合催化使用ppm级催化剂负载量实现酮的氰基硅烷化

由于非共价硫族元素键相互作用相对较弱，因此以有效方式实施硫族元素键催化仍然是一个真正的挑战。我们在此表明，即使使用低至百万分之几（ppm）含量的催化剂负载量，而在室温下几分钟内完成反应，硫族元素键合催化方法也可以实现广泛范围的酮氰基硅烷化。考虑到弱的非共价作用力的性质，这种硫族元素键合催化方法非常出色，因为它最多可以放弃10 ⁶ / h的周转频率数。

更新日期：2020-03-23

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