Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25‐hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel‐based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE‐corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults.

中文翻译：

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老年人的维生素D浓度和局灶性脑萎缩：基于体素的形态计量学研究。

维生素D与大脑健康和功能有关。我们的目标是确定较低的25-羟基维生素D（25OHD）浓度是否与老年人的局灶性脑容量减少有关。在53名老年人中（72±5岁；女性38％；平均25OHD = 67.3±20.8 nmol / L），测量了血清25OHD浓度。使用基于体素的形态计量学和CAT12软件自动分割灰质体积（GMV）。协变量是年龄，性别，教育程度，颅内总体积和季节。血清25OHD与左钙car沟中的GMV呈正相关（P  <0.05，TFCE，FWE校正）。我们发现老年人中钙卡因沟的萎缩症具有较低的25OHD浓度。