BACKGROUND Women of African ancestry (WAA) are disproportionately affected by triple-negative breast cancer (TNBC), which remains one of the most clinically challenging breast cancer (BCa) subtypes. This study investigated the prevalence of TNBC and epidemiological trends for BCa in Barbados, a Caribbean island with a high percentage of African ancestry. METHODS Pathology reports for all BCa cases between 2007 and 2016 were collected from the sole hospital in Barbados and reviewed. The clinicopathological data collected included age, tumor grade, lymph node status, and hormone receptor status as determined by immunohistochemistry. BCa data for non-Hispanic white (NHW) and non-Hispanic black (NHB) American populations were accessed from the Surveillance, Epidemiology, and End Results database. RESULTS There were 1997 BCa cases in Barbados between 2007 and 2016 for an estimated incidence rate of 135.1 per 100,000 women in Barbados (standardized to the US population, where the standardized incidence rates for NHBs and NHWs were 141.4 and 152.6 per 100,000, respectively). Age-specific incidence rates in Barbados for this period were consistently higher in younger age groups (15-59 years) in comparison with NHWs and NHBs. Between 2010 and 2016 in Barbados, a TNBC prevalence of 25% was observed, whereas TNBC prevalences of 21% and 10% were observed in NHBs and NHWs, respectively. CONCLUSIONS The BCa incidence was higher in younger Barbadian women than NHWs and NHBs, and the TNBC prevalence was ~2.5 times higher than the prevalence in NHWs. This hints at a possible genetic predisposition and other socioeconomic factors that could explain the high TNBC prevalence and aggressive clinical course in WAA globally.

中文翻译：

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巴巴多斯乳腺癌女性的三阴性乳腺癌高患病率和积极的预后因素。

背景技术非洲血统（WAA）的妇女受到三阴性乳腺癌（TNBC）的影响不成比例，三阴性乳腺癌仍是临床上最具挑战性的乳腺癌（BCa）亚型之一。这项研究调查了非洲裔比例较高的加勒比海岛屿巴巴多斯的TNBC患病率和BCa的流行病学趋势。方法从巴巴多斯唯一一家医院收集2007年至2016年所有BCa病例的病理报告并进行回顾。收集的临床病理数据包括年龄，肿瘤等级，淋巴结状态和通过免疫组织化学确定的激素受体状态。非西班牙裔白人（NHW）和非西班牙裔黑人（NHB）美国人群的BCa数据可从监测，流行病学和最终结果数据库中获取。结果2007年至2016年间，巴巴多斯共有1997例BCa病例，估计每10万名巴巴多斯女性的发病率为135.1（按美国人口标准，其中NHB和NHW的标准发病率分别为141.4和152.6 / 10万）。与NHW和NHB相比，年轻时期（15-59岁）在巴巴多斯这一时期的年龄特定发病率一直较高。在2010年至2016年之间，巴巴多斯的TNBC患病率为25％，而NHB和NHW的TNBC患病率分别为21％和10％。结论在年轻的巴巴多妇女中，BCa的发生率高于NHW和NHB，TNBC的患病率是NHW的约2.5倍。