Cardiac iron concentration in relation to systemic iron status and disease severity in non‐ischaemic heart failure with reduced ejection fraction,European Journal of Heart Failure

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Cardiac iron concentration in relation to systemic iron status and disease severity in non‐ischaemic heart failure with reduced ejection fraction
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2020-03-10 , DOI: 10.1002/ejhf.1781
Valentin G. Hirsch _{1,

2} , Jörn Tongers ₂ , Julia Bode ₃ , Dominik Berliner ₂ , Julian D. Widder ₂ , Felicitas Escher ₄ , Vitalii Mutsenko ₅ , Bomee Chung _{1,

2} , Fatemeh Rostami _{1,

2} , Anja Guba‐Quint _{1,

2} , Evangelos Giannitsis ₆ , Heinz‐Peter Schultheiss ₄ , Carla Vogt ₃ , Johann Bauersachs ₂ , Kai C. Wollert _{1,

2} , Tibor Kempf _{1,

2}

Affiliation

Low cardiac iron levels promote heart failure in experimental models. While cardiac iron concentration (CI) is decreased in patients with advanced heart failure with reduced ejection fraction (HFrEF), CI has never been measured in non‐advanced HFrEF. We measured CI in left ventricular (LV) endomyocardial biopsies (EMB) from patients with non‐advanced HFrEF and explored CI association with systemic iron status and disease severity.

中文翻译：

非缺血性心力衰竭伴射血分数降低的心脏铁浓度与全身铁状态和疾病严重性的关系

在实验模型中，低水平的铁离子可促进心力衰竭。虽然晚期心力衰竭患者射血分数（HFrEF）降低，但心脏铁浓度（CI）降低，但从未在非先进HFrEF中测量CI。我们测量了非高级HFrEF患者的左心室（LV）心肌内膜活检（EMB）中的CI，并探讨了CI与全身铁状态和疾病严重程度的相关性。

更新日期：2020-03-10

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