Enantioselective Dearomative Cyclization of Homotryptamines with Allenamides into Indolo[2,3‐b]quinolines,Advanced Synthesis & Catalysis

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Enantioselective Dearomative Cyclization of Homotryptamines with Allenamides into Indolo[2,3‐b]quinolines
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-03-30 , DOI: 10.1002/adsc.202000083
Soumen Biswas ₁ , Hanbyul Kim ₁ , Kiet Le Anh Cao ₁ , Seunghoon Shin ₁

Affiliation

We have developed a catalytic asymmetric dearomative cyclization of homotryptamine derivatives, furnishing enantioenriched indolo[2,3‐b]quinoline scaffolds. The activation of allenamides in the presence of chiral phosphoric acids triggered the dearomative cyclization in up to 99% ee.

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