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Enantioselective Vinylogous Mannich‐Type Reactions to Construct CF3S‐Containing Stereocenters Catalysed by Chiral Quaternary Phosphonium Salts
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-03-30 , DOI: 10.1002/adsc.201901621 Lijun Xu 1, 2 , Longhui Yu 2 , Jun Liu 2 , Hongyu Wang 2 , Changwu Zheng 3 , Gang Zhao 2
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-03-30 , DOI: 10.1002/adsc.201901621 Lijun Xu 1, 2 , Longhui Yu 2 , Jun Liu 2 , Hongyu Wang 2 , Changwu Zheng 3 , Gang Zhao 2
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A series of benzyl trifluoromethyl sulphides bearing a nitro group were utilized as CF3S‐containing building blocks to construct chiral CF3S‐containing molecules via enantioselective vinylogous Mannich‐type reactions. In such reactions, high yields and enantioselectivities were obtained using chiral quaternary phosphonium salts derived from amino acids. Moreover, a chiral cyclic urea bearing the CF3S moiety was obtained from further transformation of the product.
中文翻译：
对映选择性Vyloglogous Mannich型反应，以构建由CF4S手性季os盐催化的含CF3S的立体中心
一系列带有硝基的苄基三氟甲基硫化物被用作含CF 3 S的结构单元，通过对映选择性乙烯基类Mannich型反应构建手性CF 3 S分子。在这种反应中，使用衍生自氨基酸的手性季phospho盐可获得高产率和对映选择性。此外，从产物的进一步转化获得带有CF 3 S部分的手性环状脲。
更新日期：2020-03-30
中文翻译：
对映选择性Vyloglogous Mannich型反应，以构建由CF4S手性季os盐催化的含CF3S的立体中心
一系列带有硝基的苄基三氟甲基硫化物被用作含CF 3 S的结构单元，通过对映选择性乙烯基类Mannich型反应构建手性CF 3 S分子。在这种反应中，使用衍生自氨基酸的手性季phospho盐可获得高产率和对映选择性。此外，从产物的进一步转化获得带有CF 3 S部分的手性环状脲。
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