Aims 

We examined the associations of pericardial adipose tissue with cardiac structures and cardiovascular risk factors in children.

Methods and results 

We performed a cross-sectional analysis in a population-based cohort study among 2892 children aged 10 years (2404 normal weight and 488 overweight/obese). Pericardial adipose tissue mass was estimated by magnetic resonance imaging (MRI) and indexed on height³. Left ventricular mass (LVM) and left ventricular mass-to-volume ratio (LMVR) were estimated by cardiac MRI. Cardiovascular risk factors included android adipose tissue percentage obtained by Dual-energy X-ray absorptiometry, blood pressure and glucose, insulin, cholesterol, and triglycerides concentrations. Adverse outcomes were defined as values above the 75 percentile. Median pericardial adipose tissue index was 3.6 (95% range 1.6–7.1) among normal weight and 4.7 (95% range 2.0–8.9) among overweight children. A one standard deviation (1 SD) higher pericardial adipose tissue index was associated with higher LMVR [0.06 standard deviation scores, 95% confidence interval (CI) 0.02–0.09], increased odds of high android adipose tissue [odd ratio (OR) 2.08, 95% CI 1.89–2.29], high insulin concentrations (OR 1.17, 95% CI 1.06–1.30), an atherogenic lipid profile (OR 1.22, 95% CI 1.11–1.33), and clustering of cardiovascular risk factors (OR 1.56, 95% CI 1.36–1.79). Pericardial adipose tissue index was not associated with LVM, blood pressure, and glucose concentrations. The associations showed largely the same directions but tended to be weaker among normal weight than among overweight children.

Conclusion 

Pericardial adipose tissue is associated with cardiac adaptations and cardiovascular risk factors already in childhood in both normal weight and overweight children.

中文翻译：

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学龄儿童心包脂肪组织、心脏结构和心血管危险因素

宗旨 

我们检查了心包脂肪组织与儿童心脏结构和心血管危险因素的关联。

方法和结果 

我们在一项基于人群的队列研究中对 2892 名 10 岁儿童（2404 名正常体重和 488 名超重/肥胖儿童）进行了横断面分析。通过磁共振成像 (MRI) 估计心包脂肪组织质量并以高度^{3 为}索引. 左心室质量 (LVM) 和左心室质量体积比 (LMVR) 由心脏 MRI 估计。心血管危险因素包括通过双能 X 射线吸收测定法获得的机器人脂肪组织百分比、血压和葡萄糖、胰岛素、胆固醇和甘油三酯浓度。不良结果被定义为高于 75 个百分位的值。正常体重儿童的心包脂肪组织指数中位数为 3.6（95% 范围 1.6-7.1），超重儿童为 4.7（95% 范围 2.0-8.9）。一个标准差 (1 SD) 较高的心包脂肪组织指数与较高的 LMVR 相关 [0.06 标准差分数，95% 置信区间 (CI) 0.02–0.09]，增加高安卓脂肪组织的几率 [奇数比 (OR) 2.08 , 95% CI 1.89–2.29]，高胰岛素浓度（OR 1.17，95% CI 1.06–1.30），致动脉粥样硬化的血脂（OR 1.22，95% CI 1.11-1.33）和心血管危险因素的聚集（OR 1.56，95% CI 1.36-1.79）。心包脂肪组织指数与 LVM、血压和葡萄糖浓度无关。这些关联显示出大致相同的方向，但在正常体重的儿童中往往比在超重儿童中弱。

结论 

在正常体重和超重儿童中，心包脂肪组织与儿童时期已经存在的心脏适应和心血管危险因素有关。