Programming of offspring life-course health by maternal nutrition and stress are well studied. At postnatal day 850, we evaluated male and female steroid levels and metabolism in aged offspring of primigravid sister rats bred at 70, 90, 150- or 300-days’ life. At 850 days life, male offspring corticosterone was similar regardless of maternal age. Female corticosterone was highest in offspring of 70- and 300-day mothers. Serum dehydroepiandrosterone:corticosterone was lowest in both sexes of offspring of 70- and 300-day mothers. Male and female fat depots were smaller in offspring of 150 than 70- and 90-day mothers. Insulin, glucose and homeostatic model assessment were similar in all male offspring but higher in female offspring of 70-day mothers than other ages. We conclude, maternal age affects offspring aging in an offspring sex dependent manner and merits consideration in designing and interpreting programming studies.

中文翻译：

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内分泌和代谢表型的老化是通过受孕时母亲的年龄以性别依赖性方式编程的

通过母亲营养和压力对后代生命过程健康进行编程的研究非常深入。在出生后的第850天，我们评估了在70、90、150或300天的生命中繁殖的初生姐妹大鼠的老年后代中雄性和雌性类固醇水平以及新陈代谢。在850天的生命中，不论孕妇年龄如何，雄性后代皮质酮都相似。在70天和300天母亲的后代中，雌性皮质酮最高。在70天和300天母亲的后代中，血清脱氢表雄酮：皮质酮最低。150天的后代中，男性和女性的脂肪库比70天和90天的母亲要小。70天母亲的所有男性后代中的胰岛素，葡萄糖和体内稳态模型评估均相似，但女性后代中的胰岛素，葡萄糖和体内稳态模型评估结果高于其他年龄。我们得出结论，