Parkinson’s disease (PD) is a common neurodegenerative disorder resulting in motor, cognitive, psychiatric, sleep, sensory, and autonomic disturbances. The wide spectrum of morbidity is a major source for disability and impaired quality of life in patients with PD. A key pathological abnormality in PD is the loss of dopaminergic neurons in the substantia nigra resulting in loss of dopaminergic nerve terminals in the striatum. Normal aging is also associated with substantial loss of striatal dopaminergic nerve terminal function at a rate of 5%–8% per decade of adult life (1,2). Therefore, normal aging between the ages of 25–75 years may result in about half the severity of losses as those seen in PD (3). The facts that aging is a major risk for PD and that normal aging is associated with substantial loss of striatal dopaminergic nerve terminal functions raise questions about shared biological vulnerabilities.

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衰老的脆弱性和体育锻炼的生物效应为干预帕金森氏病提供了新的线索

帕金森氏病（PD）是一种常见的神经退行性疾病，会导致运动，认知，精神病，睡眠，感觉和自主神经紊乱。广泛的发病率是PD患者残疾和生活质量受损的主要来源。PD的关键病理异常是黑质中多巴胺能神经元的丧失，导致纹状体中多巴胺能神经末梢的丧失。正常的衰老还伴随着纹状体多巴胺能神经末梢功能的大量丧失，每十年的成年寿命为5％–8％（1,2）。因此，年龄在25-75岁之间的正常衰老可能导致损失的严重程度约为PD的一半（3）。