Motif-HMM (mHMM) scanning has been shown to possess unique advantages over standardly used sequence-profile search methods (e.g. HMMER, PSI-BLAST) since it is particularly well-suited to discriminate proteins with variations inside conserved motifs (e.g. family subtypes) or motifs lacking essential residues (false positives, e.g. pseudoenzymes).

中文翻译：

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主题：蛋白质基序扫描2.0。

母题-HMM（mHMM）扫描已显示出优于标准的序列图谱搜索方法（例如HMMER，PSI-BLAST）的独特优势，因为它特别适合区分保守基序内部变异的蛋白质（例如家族亚型）或缺少必要残基的基序（假阳性，例如假酶）。