High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial,Prostate Cancer and Prostatic Diseases

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High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial
Prostate Cancer and Prostatic Diseases ( IF 5.1 ) Pub Date : 2020-03-10 , DOI: 10.1038/s41391-020-0219-1
J E M Blackwell _{1,

2} , B Doleman _{1,

2} , C L Boereboom _{1,

2} , A Morton ₁ , S Williams ₁ , P Atherton ₂ , K Smith ₂ , J P Williams _{1,

2} , B E Phillips ₂ , J N Lund _{1,

2}

Affiliation

Objectives

To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks.

Subjects/patients and methods

A randomised control trial of consecutive patients aged (>65 years) scheduled for major urological surgery in a large secondary referral centre in a UK hospital. The primary outcome is change in anaerobic threshold (VO_2AT) following HIIT vs. standard care.

Results

Forty patients were recruited (mean age 72 years, male (39): female (1)) with 34 completing the protocol. Intention to treat analysis showed significant improvements in anaerobic threshold (VO_2AT; mean difference (MD) 2.26 ml/kg/min (95% CI 1.25–3.26)) following HIIT. Blood pressure (BP) also significantly reduced in following: HIIT (SBP: −8.2 mmHg (95% CI −16.09 to −0.29) and DBP: −6.47 mmHg (95% CI −12.56 to −0.38)). No reportable adverse safety events occurred during HIIT and all participants achieved >85% predicted maximum heart rate during sessions, with protocol adherence of 84%.

Conclusions

HIIT can improve CRF and cardiovascular health, representing clinically meaningful and achievable pre-operative improvements. Larger randomised trials are required to investigate the efficacy of prehabilitation HIIT upon different cancer types, post-operative complications, socio-economic impact and long-term survival.

中文翻译：

高强度间歇训练在泌尿外科癌症手术前不到 31 天内显着改善健康：一项随机对照试验

目标

评估高强度间歇训练 (HIIT) 对改善 4 周内等待切除泌尿系统恶性肿瘤患者心肺适能 (CRF) 的功效。

受试者/患者和方法

一项针对计划在英国医院大型二级转诊中心进行大泌尿外科手术的连续年龄（>65 岁）患者的随机对照试验。主要结果是HIIT 与标准治疗后无氧阈值 (VO _2AT ) 的变化。

结果

招募了 40 名患者（平均年龄 72 岁，男性 (39)：女性 (1)），其中 34 名完成了方案。意向治疗分析显示_HIIT后无氧阈值（VO _2AT；平均差异 (MD) 2.26 ml/kg/min (95% CI 1.25–3.26)）有显着改善。血压 (BP) 在以下方面也显着降低：HIIT（SBP：-8.2 mmHg（95% CI -16.09 至 -0.29）和 DBP：-6.47 mmHg（95% CI -12.56 至 -0.38））。在 HIIT 期间没有发生可报告的不良安全事件，所有参与者在训练期间达到了 >85% 的预测最大心率，协议遵守率为 84%。