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Carotid web leads to new thrombus formation: computational fluid dynamic analysis coupled with histological evidence.
Acta Neurochirurgica ( IF 1.9 ) Pub Date : 2020-03-10 , DOI: 10.1007/s00701-020-04272-2
Dan Ozaki 1 , Toshiki Endo 1 , Hiroyoshi Suzuki 2 , Shin-Ichiro Sugiyama 3 , Kaoru Endo 4 , Ryo Itabashi 4 , Miki Fujimura 1 , Teiji Tominaga 5
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Carotid web has been recognized as a rare cause of ischemic stroke with high recurrence rate. We describe a 48-year-old woman with carotid web who developed embolic stroke. We obtained a fresh thrombus from the internal carotid artery when carotid endarterectomy was performed. A preoperative computational fluid dynamics (CFD) study showed stagnation of blood around the web structure as well as the low wall shear stress. The rheological analysis newly disclosed mechanisms of thrombus formation related to the carotid web. CFD study in the carotid web may determine indication and timing of surgical interventions with further accumulation of clinical evidence.



中文翻译:

颈动脉网导致新的血栓形成:计算流体动力学分析与组织学证据相结合。

颈动脉网被认为是缺血性中风的罕见原因,复发率很高。我们描述了一名48岁的患有颈动脉网的妇女发生栓塞性中风。当进行颈动脉内膜切除术时,我们从颈内动脉获得了新鲜的血栓。术前计算流体动力学(CFD)研究显示,网状结构周围的血液停滞以及低壁切应力。流变学分析新揭示了与颈动脉网有关的血栓形成机制。颈动脉网上的CFD研究可能会确定外科手术的适应症和时机,并进一步积累临床证据。

更新日期:2020-03-10
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