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A Convenient Synthesis of Amidines via Cycloaddition–Decarboxylation of Isocyanates and Nitrones
Synthesis ( IF 2.6 ) Pub Date : 2020-03-09 , DOI: 10.1055/s-0040-1707989
Mei-Mei Zhang 1 , Yijing Wu , Xinyi Chen
Affiliation  

A base-promoted reaction between isocyanates and nitrones has been described, allowing an access to a variety of important functionalized amidines under mild reaction conditions. This strategy provides a convenient, effective, and scalable approach for the direct assembly of amidine compounds from simple starting materials in excellent yields.

中文翻译:

通过异氰酸酯和亚硝基的环加成-脱羧反应方便地合成Am

已经描述了异氰酸酯和硝酮之间的碱促进的反应,允许在温和的反应条件下获得各种重要的官能化am。该策略提供了一种方便,有效且可扩展的方法,可从简单的起始原料以优异的收率直接组装am化合物。
更新日期:2020-03-09
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