Abstract

We performed a series of novel benzamide compounds which were synthesized starting from 2,3-dimethoxybenzoic acid or 3-acetoxy-2-methylbenzoic acid and amine derivatives. All the obtained products were purified, and the analysis of these products was determined with IR, ¹H NMR, ¹³C NMR spectroscopic, and elemental methods. The in vitro antioxidant activity of all the compounds was determined by total antioxidant, free radical scavenging, and metal chelating activity. Some of synthesized compounds showed more effective total antioxidant, free radical scavenging, and metal chelating activity compared with standards. One of the benzamide compounds has been shown to exhibit effective metal chelate activity. The new compounds were determined in vitro antibacterial activity against three gram-positive bacteria and three gram-negative bacteria and compared with two control drugs. Thus, by conducting in vivo biochemical tests of effective amides, researches can be carried out in different fields of application.

Graphic abstract

We performed a series of novel benzamide compounds which were synthesized, and the analysis of these products was determined with IR, ¹H NMR, ¹³C NMR spectroscopic, and elemental methods. The in vitro antioxidant activity of all the compounds was determined by total antioxidant, free radical scavenging, and metal chelating activity. All the compounds were tested for their in vitro growth inhibitory activity against different bacteria.

中文翻译：

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新的2,3-二甲氧基和3-乙酰氧基-2-甲基苯甲酰胺的合成，表征，抗氧化和抗菌活性

摘要

我们进行了一系列从2,3-二甲氧基苯甲酸或3-乙酰氧基-2-甲基苯甲酸与胺衍生物合成的新型苯甲酰胺化合物。纯化所有获得的产物，并用IR，¹ H NMR，¹³测定这些产物的分析。13 C NMR光谱和元素方法。所有化合物的体外抗氧化活性由总抗氧化剂，自由基清除和金属螯合活性确定。与标准品相比，某些合成的化合物显示出更有效的总抗氧化剂，自由基清除和金属螯合活性。苯甲酰胺化合物之一已显示出有效的金属螯合活性。测定了新化合物对三种革兰氏阳性细菌和三种革兰氏阴性细菌的体外抗菌活性，并与两种对照药物进行了比较。因此，通过进行有效酰胺的体内生化测试，可以在不同的应用领域中进行研究。

图形摘要

我们进行了一系列合成的新型苯甲酰胺化合物的合成，并使用IR，¹ H NMR，¹³ C NMR光谱和元素方法对这些产物进行了分析。所有化合物的体外抗氧化活性由总抗氧化剂，自由基清除和金属螯合活性确定。测试所有化合物对不同细菌的体外生长抑制活性。