The RAS oncoprotein drives elevated macropinocytosis, a metabolic process essential for cancer growth. A recent study by Ramirez et al. elucidated a mechanism whereby RAS controls V-ATPase association with the plasma membrane to drive RAC1 GTPase-dependent macropinocytosis. Potentially actionable targets to disrupt this RAS-dependent nutrient acquisition pathway were identified.

中文翻译：

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暴饮暴食：巨噬细胞增多促进RAS突变型癌症的致瘤性生长。

RAS癌蛋白驱动巨噬细胞增多，这是癌症生长必不可少的代谢过程。拉米雷斯等人的最新研究。阐明了一种机制，其中RAS控制V-ATPase与质膜的结合，以驱动RAC1 GTPase依赖的巨胞饮作用。确定了潜在的可操作目标，以破坏这种RAS依赖的养分获取途径。