Pyroptosis, a form of programmed cell death, has garnered increasing attention as it relates to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing various challenges expands the spectrum of pyroptosis mediators and also reveals that pyroptosis is not cell type specific. Recent studies have identified that pyroptosis has become a new topic in cancer research because it may affect all stages of carcinogenesis. In this mini-review, we provided a primer on pyroptosis, discussed the induction of pyroptosis in cancer and its implications in cancer management. Moreover, its two important executioners, the gasdermin D (GSDMD) and gasdermin E (GSDME), the functions and mechanisms of them involved in the regulation of cancer therapy were focused on. Small molecules-mediated pyroptosis were found to effectively inhibit various tumor cells. In brief, the findings of pyroptosis-dependent cancer progression, new drugs and therapeutic targets may lead to a promising, novel therapeutic approach for cancer patients.

中文翻译：

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细胞凋亡介导的癌细胞死亡机制和调控。

细胞凋亡是程序性细胞死亡的一种形式，由于它与先天免疫和疾病有关，因此引起了越来越多的关注。caspase-1 / 3/4/5/8/11在感知各种挑战中的功能的发现扩大了焦磷酸化介体的范围，也揭示了焦磷酸化不是细胞类型特异性的。最近的研究已经确定，热凋亡已成为癌症研究中的一个新话题，因为它可能影响癌变的所有阶段。在本微型审查中，我们提供了有关热凋亡的入门知识，讨论了癌症中热凋亡的诱导及其在癌症管理中的意义。此外，还关注了其两个重要的执行者，即加德敏D（GSDMD）和加德敏E（GSDME），它们在调节癌症治疗中的功能和机制。发现小分子介导的细胞凋亡可以有效抑制各种肿瘤细胞。简而言之，对热病依赖的癌症进展，新药和治疗靶点的发现可能会为癌症患者带来有希望的新颖治疗方法。