Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) and T cell-mediated autoimmune processes are assumed to be involved in its pathogenesis. Recently, accumulating evidence has indicated that commensal bacteria interact with the host immune system and that the alteration of commensal bacteria composition, termed dysbiosis, is associated with various autoimmune diseases including CNS autoimmune diseases. In this review, we introduce recent findings regarding the association between gut microbiota and MS and related diseases and microbiota function in an animal model of MS.

中文翻译：

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肠道菌群失调和多发性硬化

多发性硬化症 (MS) 是一种中枢神经系统 (CNS) 的炎症性疾病，T 细胞介导的自身免疫过程被认为与其发病机制有关。最近，越来越多的证据表明，共生细菌与宿主免疫系统相互作用，并且共生细菌组成的改变，称为生态失调，与包括中枢神经系统自身免疫性疾病在内的各种自身免疫性疾病有关。在这篇综述中，我们介绍了关于肠道微生物群与 MS 以及相关疾病和微生物群功能在 MS 动物模型中的关系的最新发现。