The relationship between microRNA (miR) and immune activity in allergic rhinitis (AR) remains unclear. 37 children with AR and 30 healthy children were enrolled to study the correlation of miR-223 and IL-35. There was a significant inverse correlation between plasma levels of IL-35 and serum eosinophil cationic protein (ECP) levels and eosinophils counts, while there was a positive correlation between serum miR-223 level and ECP levels and eosinophils counts. Besides, the serum levels of IL-35 or miR-223 were found to be negatively or positively correlated with TNSS respectively. The serum level of miR-223 was increased, while IL-35 level was decreased. Moreover, the expression of miRNA-223 was inversely correlated with expression of IL-35. Finally, the levels of miR-223 and IL-35 were related to Th1/Th2 cytokines, eosinophils count as well as the clinical severity. Our study suggests the potential of miR-223 and IL-35 as a molecular target for the treatment of AR.

中文翻译：

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miR-223和IL-35与过敏性鼻炎患儿的调节作用相关。

microRNA（miR）与变应性鼻炎（AR）免疫活性之间的关系尚不清楚。研究纳入了37例AR儿童和30例健康儿童，以研究miR-223和IL-35的相关性。血浆IL-35水平与血清​​嗜酸性粒细胞阳离子蛋白（ECP）水平和嗜酸性粒细胞计数之间呈显着负相关，而血清miR-223水平与ECP水平和嗜酸性粒细胞计数之间呈正相关。此外，血清IL-35或miR-223水平与TNSS呈负相关或正相关。miR-223的血清水平升高，而IL-35的水平降低。而且，miRNA-223的表达与IL-35的表达负相关。最后，miR-223和IL-35的水平与Th1 / Th2细胞因子有关，嗜酸性粒细胞的数量以及临床严重程度。我们的研究表明，miR-223和IL-35作为治疗AR的分子靶标的潜力。