The gut microbiota (GM) is referred to as the second gene pool of the human body and a commensal, symbiotic, and pathogenic microorganism living in our intestines. The knowledge of the complex interaction between intestinal microbiota and health outcomes is a novel and rapidly expanding the field. Earlier studies have reported that the microbial communities affect the cellular responses and shape many aspects of physiology and pathophysiology within the body, including muscle and bone metabolism (formation and resorption). GM influences the skeletal homeostasis via affecting the host metabolism, immune function, hormone secretion, and the gut-brain axis. The premise of this review is to discuss the role of GM on bone homeostasis and skeletal muscle mass function. This review also opens up new perspectives for pathophysiological studies by establishing the presence of a 'microbiota-skeletal' axis and raising the possibility of innovative new treatments for skeletal development.

中文翻译：

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肠道菌群在骨稳态中的作用

肠道微生物群 (GM) 被称为人体的第二个基因库，是生活在我们肠道中的共生、共生和病原微生物。肠道微生物群与健康结果之间复杂相互作用的知识是一个新颖且迅速扩展的领域。早期的研究报告称，微生物群落影响细胞反应并塑造体内生理学和病理生理学的许多方面，包括肌肉和骨骼代谢（形成和吸收）。转基因通过影响宿主代谢、免疫功能、激素分泌和肠脑轴来影响骨骼稳态。本综述的前提是讨论 GM 对骨稳态和骨骼肌质量功能的作用。