Phthalocyanines have interesting optoelectronic properties but typically suffer from aggregation in aqueous solution, which can limit their applicability, especially in photodynamic therapy. In this study, indium(III) phthalocyanine peripherally substituted with eight triazolyl-containing phenoxy groups (InOAc) and its water-soluble analogue (Q-InOAc) were synthesised and structurally characterised. Heavy metal effects, exerted by the central indium ion, on the photosensitising and photophysical properties (singlet oxygen quantum yield, singlet state lifetime and quantum yield, and triplet state lifetime) were investigated in both DMF and D₂O. Highly efficient generation of the triplet excited state (T1), induced by the incorporation of a large atom, enhanced singlet oxygen formation, as revealed by both chemical and physical methods. Correspondingly, the singlet oxygen quantum yield (Φ_Δ) of Q-InOAc was 0.603 in DMF and 0.433 in D₂O. These values are higher than those previously reported for the corresponding metal-free, Mg-based, and Zn-based water-soluble phthalocyanines (HH, Mg, and Zn). Consequently, Q-InOAc is expected to be an excellent photosensitiser for photodynamic therapy.

酞菁具有令人感兴趣的光电特性，但通常会在水溶液中发生聚集，这会限制其适用性，尤其是在光动力疗法中。在这项研究中，合成了被八个含三唑基的苯氧基（InOAc）外围取代的铟（III）酞菁及其水溶性类似物（Q-InOAc），并对其结构进行了表征。在DMF和D ₂中研究了中心铟离子对光敏化和光物理性质（单氧量子产率，单重态寿命和量子产率以及三重态寿命）产生的重金属效应。O.通过结合大原子诱导的三重态激发态（T1）的高效生成，增强了单线态氧的形成，这在化学和物理方法中都可以看出。相应地，单线态氧量子产率（Φ _Δ）的Q-INOAC是0.603在DMF和d 0.433 ₂ O.这些值比以前用于相应不含金属的，基于Mg和Zn基水报道的那些更高可溶性酞菁（HH，Mg和Zn）。因此，预期Q-InOAc是用于光动力疗法的优秀光敏剂。