Gelatin (GN) is a polymer, which is similar to the protein derived from collagen, an organic element in the bone. GN can incorporate into the mineral part of the bone, hydroxyapatite (HA). The HA bioceramic has properties very close to the natural bone characteristics. Therefore, in this research, bio-nanocomposite scaffolds made of the HA composed with magnetite nanoparticles (MNPs) are fabricated. For this purpose, the space holder technique is put to use using NaCl particles as the spacers. The HA-X%MNP (X = 0 wt%, 5 wt%, 10 wt%, and 15 wt%) scaffolds are coated via gelatin-ibuprofen (GN-IBO) in order to determine the capabilities of the scaffolds for compatibility and fibroblastic cells of the related tissue. The coated bio-nanocomposite scaffolds are characterized using scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) tools. Then, the porosity and bioactivity of the prepared samples are tested in the simulated body fluid (SBF), and the associated compressive strength, fracture toughness, porosity and hardness are investigated. Also, the magnetic behavior of the scaffolds during the release of IBO in the phosphate buffer saline (PBS) is monitored after 21 days incubation. Finally, an analytical sandwich plate model is developed to analyze the vibrational response of an axially loaded plate-type HA-MNP bio-nanocomposite implants. The obtained X-ray diffraction (XRD) confirms the presence of IBO peaks after removing the samples from the PBS which proves the lower release speed of the sample containing 10 wt% MNPs. It is found that the interaction between IBO and HA affects the mechanical performance of the scaffolds. IBO release profiles present a burst release that depends on the HA content. The given results indicate that the manufactured scaffolds have good potentials for biological as well as hyperthermia applications in bone tissue engineering.

明胶（GN）是一种聚合物，类似于源自胶原蛋白（骨骼中的有机元素）的蛋白质。GN可以将羟磷灰石（HA）掺入骨骼的矿物质部分。HA生物陶瓷具有非常接近天然骨骼特征的特性。因此，在这项研究中，由HA制成的生物纳米复合支架由磁铁矿纳米颗粒（MNP）组成。为此，使用了NaCl颗粒作为间隔物的空间保持器技术。HA-X％MNP（X = 0 wt％，5 wt％，10 wt％和15 wt％）支架通过明胶-布洛芬（GN-IBO）进行涂覆，以确定支架的相容性和相关组织的成纤维细胞。使用扫描电子显微镜（SEM）和能量分散光谱（EDS）工具对涂层的生物纳米复合材料支架进行表征。然后，在模拟体液（SBF）中测试所制备样品的孔隙率和生物活性，并研究相关的抗压强度，断裂韧性，孔隙率和硬度。同样，在21天的温育后，监测在磷酸盐缓冲盐水（PBS）中IBO释放期间支架的磁性行为。最后，建立了一个分析夹心板模型来分析轴向加载的板式HA-MNP生物纳米复合材料植入物的振动响应。从PBS中除去样品后，获得的X射线衍射（XRD）证实了IBO峰的存在，这证明了含有10wt％MNP的样品的释放速度较低。发现IBO和HA之间的相互作用影响支架的机械性能。IBO发布配置文件提供了取决于HA内容的突发发布。给出的结果表明，所制造的支架在骨组织工程中具有生物学和热疗应用的良好潜力。