Gut microbiota and aging-A focus on centenarians.,Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

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Gut microbiota and aging-A focus on centenarians.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ( IF 4.2 ) Pub Date : 2020-03-10 , DOI: 10.1016/j.bbadis.2020.165765
Adriana Florinela Cӑtoi ₁ , Andreea Corina ₂ , Niki Katsiki ₃ , Dan Cristian Vodnar ₄ , Andra Diana Andreicuț ₁ , Anca Pantea Stoian ₅ , Manfredi Rizzo ₆ , Pablo Pérez-Martínez ₂

Affiliation

Gut microbiota (GM) is a dynamic organ throughout the lifespan. Aging is a complex process that comprises a plethora of mechanisms such as senescence, immunosenescence and inflammaging, representing important pathways of age-related diseases. GM structure could both influence and be influenced by aging occurring changes within the host. A unique category of long living individuals exists, namely centenarians that have the outstanding capacity to adapt to various challenges. Longevity seems to be associated with certain GM which, among other factors, might render individuals more resistant to age-related diseases and subsequently to long living. Diet, prebiotics, probiotics and synbiotics may contribute to longevity through GM modulating. Currently, the exact mechanisms of the association between GM and the host in relation with extended lifespan remain unknown and should be further investigated.

中文翻译：

肠道菌群和衰老-着重于百岁老人。

肠道菌群（GM）是整个生命周期中的动态器官。衰老是一个复杂的过程，它包括许多机制，例如衰老，免疫衰老和发炎，代表了与年龄有关的疾病的重要途径。GM结构既可以影响宿主内部发生的老化变化，也可以受到其影响。存在一个独特的长寿个体类别，即百岁老人，他们具有出色的适应各种挑战的能力。长寿似乎与某些基因改造有关，除其他因素外，基因改造可能使个体对与年龄有关的疾病以及随后的长寿更具抵抗力。饮食，益生元，益生菌和合生元可能通过基因改造来延长寿命。目前，

更新日期：2020-04-20

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