Bronchopulmonary dysplasia (BPD) is a devastating chronic neonatal lung disease leading to serious adverse consequences. Nearly 15 million babies are born preterm accounting for >1 in 10 births globally. The aetiology of BPD is multifactorial and the survivors suffer lifelong respiratory morbidity. Lysophospholipids (LPL), which include sphingosine-1-phosphate (S1P), and lysophosphatidic acid (LPA) are both naturally occurring bioactive lipids involved in a variety of physiological and pathological processes such as cell survival, death, proliferation, migration, immune responses and vascular development. Altered LPL levels have been observed in a number of lung diseases including BPD, which underscores the importance of these signalling lipids under normal and pathophysiological situations. Due to the paucity of information related to LPLs in BPD, most of the ideas related to BPD and LPL are speculative. This article is intended to promote discussion and generate hypotheses, in addition to the limited review of information related to BPD already established in the literature.

中文翻译：

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了解溶血磷脂及其受体在包括支气管肺发育不良在内的肺部疾病中的作用的进展。


支气管肺发育不良（BPD）是一种毁灭性的慢性新生儿肺部疾病，可导致严重的不良后果。全球有近 1500 万婴儿早产，占新生儿总数的十分之一以上。 BPD 的病因是多因素的，幸存者终生患有呼吸道疾病。溶血磷脂 (LPL)，包括 1-磷酸鞘氨醇 (S1P) 和溶血磷脂酸 (LPA) 都是天然存在的生物活性脂质，参与多种生理和病理过程，如细胞存活、死亡、增殖、迁移、免疫反应和血管发育。在包括 BPD 在内的许多肺部疾病中都观察到 LPL 水平的改变，这强调了这些信号脂质在正常和病理生理情况下的重要性。由于 BPD 中与 LPL 相关的信息很少，因此大多数与 BPD 和 LPL 相关的想法都是推测性的。本文旨在除了对文献中已经建立的 BPD 相关信息进行有限回顾之外，还旨在促进讨论并提出假设。