Malaria remains a serious worldwide health danger and massive economic trouble to disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide. The emergence of fighting of the Plasmodium parasite against the first-line antimalarial drugs has fueled research attention in the way of designing new scaffolds as well as strategies to counter the drug resistance. Chalcones are simple and well-known analogs, which were found in a huge number of natural compounds and also been prepared according to their suitable synthetic approaches. This review illustrates the current progresses on structure-activity relationship (SAR) and mechanism of diverse types of chalcone derivatives that play a significant role for the development of novel safe, less toxic and highly active antimalarials. This present mini-review will be useful to scientists in research fields of medicinal chemistry, organic synthesis, and also various biological applications particularly for the development of novel antiplasmodial and antimalarial agents.

疟疾仍然是世界范围内严重的健康威胁，并给疾病流行国家带来了巨大的经济麻烦。目前，全世界预计有2.5亿疟疾病例。疟原虫战斗的出现一线抗疟药的寄生虫在设计新支架以及对抗耐药性的策略方面引起了研究关注。查耳酮是简单且众所周知的类似物，存在于大量天然化合物中，并根据其合适的合成方法制备。这项审查说明了当前的结构-活性关系（SAR）和各种类型的查尔酮衍生物的机制方面的进展，这些查尔酮衍生物在开发新型安全，低毒和高活性的抗疟疾药物中发挥着重要作用。这份最新的综述对药物化学，有机合成以及各种生物学应用领域的科学家特别有用，特别是对于新型抗血浆药物和抗疟疾药物的开发。