The triglyceride glucose (TyG) index, a simple surrogate estimate of insulin resistance, has been demonstrated to predict cardiovascular (CV) disease morbidity and mortality in the general population and many patient cohorts. However, to our knowledge, the prognostic usefulness of the TyG index after percutaneous coronary intervention (PCI) in patients with type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS) has not been determined. This study aimed to evaluate the association of the TyG index with adverse CV outcomes in patients with T2DM and ACS who underwent PCI. The TyG index was calculated using the formula ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. The primary endpoint was the composite of all-cause mortality, non-fatal stroke, non-fatal myocardial infarction, or unplanned repeat revascularization. The association between the TyG index and adverse CV outcomes was assessed by Cox proportional hazards regression analysis. In total, 776 patients with T2DM and ACS who underwent PCI (mean age, 61 ± 10 years; men, 72.2%) were included in the final analysis. Over a median follow-up of 30 months, 188 patients (24.2%) had at least 1 primary endpoint event. The follow-up incidence of the primary endpoint rose with increasing TyG index tertiles. The multivariate Cox proportional hazards regression analysis adjusted for multiple confounders revealed a hazard ratio for the primary endpoint of 2.17 (95% CI 1.45–3.24; P for trend = 0.001) when the highest and lowest TyG index tertiles were compared. The TyG index was significantly and positively associated with adverse CV outcomes, suggesting that the TyG index may be a valuable predictor of adverse CV outcomes after PCI in patients with T2DM and ACS.

中文翻译：

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甘油三酸酯葡萄糖指数可预测2型糖尿病和急性冠脉综合征患者经皮冠状动脉介入治疗后的心血管结局。

甘油三酸酯葡萄糖（TyG）指数是胰岛素抵抗的简单替代估计，已被证明可预测普通人群和许多患者队列中的心血管（CV）疾病发病率和死亡率。然而，据我们所知，尚未确定2型糖尿病（T2DM）和急性冠脉综合征（ACS）患者经皮冠状动脉介入治疗（PCI）后TyG指数的预后价值。这项研究旨在评估接受PCI的T2DM和ACS患者的TyG指数与不良CV结果的相关性。使用公式1n [空腹甘油三酸酯（mg / dL）×空腹葡萄糖（mg / dL）/ 2]计算TyG指数。主要终点是全因死亡率，非致命性中风，非致命性心肌梗塞或计划外的重复血运重建的综合结果。TyG指数与不良CV结果之间的关联通过Cox比例风险回归分析进行评估。最终分析共纳入776例行PCI的T2DM和ACS患者（平均年龄61±10岁；男性72.2％）。在30个月的中位随访中，有188例患者（24.2％）发生了至少1次主要终点事件。主要终点的随访发生率随TyG指数三分位数的增加而增加。对多个混杂因素进行校正后的多元Cox比例风险回归分析显示，当比较最高和最低TyG指数三分位数时，主要终点的风险比为2.17（95％CI 1.45–3.24；趋势P = 0.001）。TyG指数与不良CV结果显着正相关，