当前位置: X-MOL 学术BMC Nephrol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Global diastolic strain rate for the assessment of left ventricular diastolic dysfunction in young peritoneal dialysis patients: a case control study.
BMC Nephrology ( IF 2.3 ) Pub Date : 2020-03-10 , DOI: 10.1186/s12882-020-01742-8
Jing Zhu 1 , Fei Shi 1 , Tao You 1 , Chao Tang 1 , Jianchang Chen 1
Affiliation  

Left ventricular (LV) myocardial longitudinal diastolic strain rate measured by two-dimensional speckle tracking imaging (2D-STI) was proved to have a better correlation with the LV diastolic function. We aimed to use this sensitive tool to predict LV myocardial diastolic dysfunction in young peritoneal dialysis (PD) patients with preserved LV ejection fraction (LVEF). We enrolled 30 PD patients aged ≤60 with LVEF ≥54% and classified as normal LV diastolic function by conventional echocardiography, and 30 age- and sex-matched healthy people as the control group. The left atrial maximum volume index (LAVI), LV mass index (LVMI), LVEF, LV posterior wall thickness (LVPWT), interventricular septal thickness (IVST), peak velocity of tricuspid regurgitation (TR), peak early diastolic velocity/late diastolic velocity (by Pulsed Doppler) (E/A) and E/peak velocity of the early diastolic wave (by Pulsed-wave tissue Doppler) (E/e’) were recorded by conventional echocardiographic. Next, the average LV global longitudinal systolic strain (GLS avg) and the average LV global longitudinal diastolic strain rate (DSr avg) during early diastole (DSrE avg), late diastole (DSrA avg) and isovolumic relaxation period (DSrIVR avg) were obtained from 2D-STI. Combined them with E, the new noninvasive indexes (E/DSrE avg., E/DSrA avg. and E/DSrIVR avg) were derived. The PD group ‘s LVEF, E/e′, TR and LAVI were in the normal range compared with the controls, and only e′ (p < 0.001) was decreased. The LVMI (p < 0.001), LVPWT (p < 0.001), IVST (p < 0.001) increased while E/A (p < 0.001) decreased. The GLS avg. (p = 0.008) was significantly decreased in PD patients compared with the controls. DSrA avg. (p = 0.006) and E/DSrE avg. (p = 0.006) were increased, while DSrE avg. (p < 0.001), DSrIVR avg. (p = 0.017) and E/DSrA avg. (p < 0.001) decreased. After the multivariable regression analysis, the correlation between DSrE and the conventional parameters including LVPWT (p < 0.001), E/A (p < 0.001) still remained significant. Young PD patients with preserved LVEF already exhibited myocardial diastolic dysfunction. Global diastolic strain rate indexes were valuable parameters to evaluate diastolic dysfunction. Additionally, LVPWT was highly correlated with DSrE, such parameter should be taken into account for predicting the early LV diastolic dysfunction in clinical practice.

中文翻译:

用于评估年轻腹膜透析患者左室舒张功能障碍的总体舒张应变率:一项病例对照研究。

二维散斑跟踪成像(2D-STI)测量的左心室(LV)心肌纵向舒张应变率被证明与LV舒张功能具有更好的相关性。我们旨在使用这种敏感工具来预测LV射血分数(LVEF)保持不变的年轻腹膜透析(PD)患者的LV心肌舒张功能障碍。我们招募了30名LVEF≥54%且LVEF≥54%且≤LVPD≥60%的PD患者,并以30名年龄和性别相匹配的健康人作为对照组。左心房最大容积指数(LAVI),左室重量指数(LVMI),左室射血分数(LVEF),左室后壁厚度(LVPWT),室间隔厚度(IVST),三尖瓣关闭不全的峰值速度(TR),通过常规超声心动图记录舒张早期峰值速度/舒张后期晚期速度(通过脉冲多普勒)(E / A)和舒张早期波的E /峰值速度(通过脉冲波组织多普勒)(E / e')。接下来,获得舒张早期(DSrE avg),舒张末期(DSrA avg)和等容舒张期(DSrIVR avg)期间的平均LV总体纵向收缩应变(GLS avg)和平均LV总体纵向舒张应变率(DSr avg)。来自2D-STI。将它们与E结合,得出新的非侵入性指数(E / DSrE平均,E / DSrA平均和E / DSrIVR平均)。与对照组相比,PD组的LVEF,E / e',TR和LAVI均处于正常范围,只有e'降低(p <0.001)。LVMI(p <0.001),LVPWT(p <0.001),IVST(p <0.001)增加,而E / A(p <0.001)减少。GLS平均。与对照组相比,PD患者(p = 0.008)显着降低。DSrA平均。(p = 0.006)和E / DSrE平均。(p = 0.006)增加,而DSrE平均。(p <0.001),DSrIVR平均。(p = 0.017)和E / DSrA平均。(p <0.001)降低。经过多变量回归分析后,DSrE与包括LVPWT(p <0.001),E / A(p <0.001)的常规参数之间的相关性仍然很显着。LVEF保留的年轻PD患者已经表现出心肌舒张功能障碍。全球舒张应变率指数是评估舒张功能障碍的有价值的参数。此外,LVPWT与DSrE高度相关,在临床实践中应考虑此类参数以预测早期LV舒张功能障碍。与对照组相比,PD患者的008)明显降低。DSrA平均。(p = 0.006)和E / DSrE平均。(p = 0.006)增加,而DSrE平均。(p <0.001),DSrIVR平均。(p = 0.017)和E / DSrA平均。(p <0.001)降低。经过多变量回归分析后,DSrE与包括LVPWT(p <0.001),E / A(p <0.001)的常规参数之间的相关性仍然很显着。LVEF保留的年轻PD患者已经表现出心肌舒张功能障碍。全球舒张应变率指标是评估舒张功能障碍的有价值的参数。此外,LVPWT与DSrE高度相关,在临床实践中应考虑此类参数以预测早期LV舒张功能障碍。与对照组相比,PD患者的008)明显降低。DSrA平均。(p = 0.006)和E / DSrE平均。(p = 0.006)增加,而DSrE平均。(p <0.001),DSrIVR平均。(p = 0.017)和E / DSrA平均。(p <0.001)降低。经过多变量回归分析后,DSrE与包括LVPWT(p <0.001),E / A(p <0.001)的常规参数之间的相关性仍然很显着。LVEF保留的年轻PD患者已经表现出心肌舒张功能障碍。全球舒张应变率指数是评估舒张功能障碍的有价值的参数。此外,LVPWT与DSrE高度相关,在临床实践中应考虑此类参数以预测早期LV舒张功能障碍。而DSrE平均 (p <0.001),DSrIVR平均。(p = 0.017)和E / DSrA平均。(p <0.001)降低。经过多变量回归分析后,DSrE与包括LVPWT(p <0.001),E / A(p <0.001)的常规参数之间的相关性仍然很显着。LVEF保留的年轻PD患者已经表现出心肌舒张功能障碍。全球舒张应变率指标是评估舒张功能障碍的有价值的参数。此外,LVPWT与DSrE高度相关,在临床实践中应考虑此类参数以预测早期LV舒张功能障碍。而DSrE平均 (p <0.001),DSrIVR平均。(p = 0.017)和E / DSrA平均。(p <0.001)降低。经过多变量回归分析后,DSrE与包括LVPWT(p <0.001),E / A(p <0.001)的常规参数之间的相关性仍然很显着。LVEF保留的年轻PD患者已经表现出心肌舒张功能障碍。全球舒张应变率指标是评估舒张功能障碍的有价值的参数。此外,LVPWT与DSrE高度相关,在临床实践中应考虑此类参数以预测早期LV舒张功能障碍。0.001),E / A(p <0.001)仍然很显着。LVEF保留的年轻PD患者已经表现出心肌舒张功能障碍。全球舒张应变率指标是评估舒张功能障碍的有价值的参数。此外,LVPWT与DSrE高度相关,在临床实践中应考虑此类参数以预测早期LV舒张功能障碍。0.001),E / A(p <0.001)仍然很显着。LVEF保留的年轻PD患者已经表现出心肌舒张功能障碍。全球舒张应变率指标是评估舒张功能障碍的有价值的参数。此外,LVPWT与DSrE高度相关,在临床实践中应考虑此类参数以预测早期LV舒张功能障碍。
更新日期:2020-03-10
down
wechat
bug