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Statin prescription among patients with type 2 diabetes in Botswana: findings and implications
BMC Endocrine Disorders ( IF 2.8 ) Pub Date : 2020-03-10 , DOI: 10.1186/s12902-020-0516-7
Julius Chacha Mwita , Brian Godman , Tonya M. Esterhuizen

There is evidence of statin benefit among patients with diabetes regardless of cholesterol levels or prior cardiovascular disease history. Despite the evidence, there is under-prescription of statins in clinical practice. This study aimed to assess statin prescriptions and associated factors among patients with type 2 diabetes in Botswana. The study was a secondary data analysis of 500 randomly selected type 2 diabetes patients at a specialised diabetes clinic at Gaborone, Botswana. We assessed the proportion of statin-eligible patients who are prescribed statins and evaluated the adjusted associations between various factors and statin prescriptions. Overall, 477 (95.4%) participants were eligible for a statin prescription. Clinicians prescribed statins in 217 (45.5%) of eligible participants, and only one (4.4%) ineligible participant. The probability of a statin prescription was higher in participants with high baseline low-density lipoprotein cholesterol (risk ratio [RR]: 1.49; 95%CI: 1.17–1.89), increasing duration of diabetes (RR: 1.01; 95%CI 1.00–1.03) and the presence of chronic kidney disease (RR: 1.35; 95%CI: 1.06–1.74). A large proportion with type 2 diabetes in Gaborone is not receiving statins. Clinicians did not consider most guideline-recommended indications for statin prescriptions. The findings call for improvement in diabetes quality of care by implementing evidence-based guideline recommendations.

中文翻译:

博茨瓦纳2型糖尿病患者的他汀类药物处方:发现和意义

有证据表明,不管胆固醇水平或先前的心血管疾病史如何,他汀类药物对糖尿病患者的益处。尽管有证据,但在临床实践中他汀类药物处方不足。这项研究旨在评估博茨瓦纳2型糖尿病患者的他汀类药物处方和相关因素。这项研究是在博茨瓦纳哈博罗内一家专门的糖尿病诊所对500名随机选择的2型糖尿病患者进行的二级数据分析。我们评估了接受他汀类药物处方的符合他汀类药物的患者的比例,并评估了各种因素与他汀类药物处方之间的调整关联。总体上,有477名(95.4%)参与者有资格使用他汀类药物处方。临床医师在217名(45.5%)的合格参与者中处方了他汀类药物,而只有一名(4.4%)不合格的参与者处方了他汀类药物。基线低密度脂蛋白胆固醇水平高的参与者服用他汀类药物的可能性更高(风险比[RR]:1.49; 95%CI:1.17-1.89),糖尿病持续时间增加(RR:1.01; 95%CI 1.00– 1.03)和存在慢性肾脏疾病(RR:1.35; 95%CI:1.06-1.74)。哈博罗内有很大比例的2型糖尿病患者未接受他汀类药物。临床医生并未考虑大多数指南推荐的他汀类药物处方适应症。这些发现呼吁通过实施循证指南来改善糖尿病的护理质量。95%CI:1.06-1.74)。哈博罗内有很大比例的2型糖尿病患者未接受他汀类药物。临床医生并未考虑大多数指南推荐的他汀类药物处方适应症。这些发现呼吁通过实施循证指南来改善糖尿病的护理质量。95%CI:1.06-1.74)。哈博罗内有很大比例的2型糖尿病患者未接受他汀类药物。临床医生并未考虑大多数指南推荐的他汀类药物处方适应症。这些发现呼吁通过实施循证指南来改善糖尿病的护理质量。
更新日期:2020-04-22
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