Protein Detection using Quadratic Fit Analysis Near Dirac Point of Graphene Field Effect Biosensors.,ACS Applied Electronic Materials

当前位置： X-MOL 学术 › ACS Appl. Electron. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Protein Detection using Quadratic Fit Analysis Near Dirac Point of Graphene Field Effect Biosensors.
ACS Applied Electronic Materials ( IF 4.3 ) Pub Date : 2020-03-10 , DOI: 10.1021/acsaelm.9b00840
Sung Oh Woo ₁ , James Froberg ₁ , Yanxiong Pan ₂ , Sakurako Tani ₁ , Brett R Goldsmith ₃ , Zhongyu Yang ₂ , Yongki Choi _{1,

4}

Affiliation

Although graphene-based biosensors provide extreme sensitivity for the detection of atoms, gases, and biomolecules, the specificity of graphene biosensors to the target molecules requires surface decoration of graphene with bifunctional linkers such as pyrene derivatives. Here, we demonstrate that the pyrene functionalization influences graphene’s electrical properties by yielding partial formation of bilayer graphene, which was confirmed by the Raman 2D spectrum. Based on this observation, we introduce quadratic fit analysis of the nonlinear electrical behavior of pyrene-functionalized graphene near the Dirac point. Compared to the conventional linear fit analysis of the transconductance at a distance from the Dirac point, the quadratic fit analysis of the nonlinear transconductance near the Dirac point increased the overall protein detection sensitivity by a factor of 5. Furthermore, we show that both pyrene linkers and gating voltage near the Dirac point play critical roles in sensitive and reliable detection of proteins’ biological activities with the graphene biosensors.

中文翻译：

在石墨烯场效应生物传感器的狄拉克点附近使用二次拟合分析进行蛋白质检测。

尽管基于石墨烯的生物传感器为原子，气体和生物分子的检测提供了极高的灵敏度，但石墨烯生物传感器对目标分子的特异性要求对石墨烯进行表面修饰，并使用双官能连接剂（例如pyr衍生物）进行修饰。在这里，我们证明了functional官能化通过产生双层石墨烯的部分形成而影响石墨烯的电性能，这已通过拉曼二维光谱得到了证实。基于此观察，我们介绍了Dirac点附近of官能化石墨烯的非线性电学行为的二次拟合分析。与Dirac点相距一定距离的常规跨导线性拟合分析相比，

更新日期：2020-03-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11