Iron‐Catalyzed Asymmetric Inter‐ and Intramolecular Aerobic Oxidative Dearomatizing Spirocyclization of 2‐Naphthols,Asian Journal of Organic Chemistry

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Iron‐Catalyzed Asymmetric Inter‐ and Intramolecular Aerobic Oxidative Dearomatizing Spirocyclization of 2‐Naphthols
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-09 , DOI: 10.1002/ajoc.202000094
Takuya Oguma ₁ , Daiki Doiuchi ₁ , Chisaki Fujitomo ₁ , Chungsik Kim ₂ , Hiroki Hayashi ₃ , Tatsuya Uchida _{2,

3} , Tsutomu Katsuki ₂

Affiliation

Iron–salan complexes have led to highly chemo‐ and enantioselective inter‐ and intra‐molecular oxidative spirocyclization of arenols. Under the iron‐catalyzed oxidation conditions, arenols were oxidized to electrophilic radical intermediates in a chemoselective manner via single electron transfer and relating enantioselective nucleophilic dearomatizing cyclization to form spirocyclic compounds. The reaction can use molecular oxygen, the most abundant and ubiquitous hydrogen acceptor on Earth, as the oxidant. It is thought that these results are important knowledge for the development of iron catalysis. More information can be found in the Full Paper by Tatsuya Uchida et al.

中文翻译：

铁催化2-萘酚的不对称分子间和分子内好氧氧化脱芳香化螺旋环化

铁-salan配合物导致了槟榔的高度化学和对映选择性分子间和分子内氧化螺环化。在铁催化的氧化条件下，通过单电子转移和相关的对映选择性亲核脱芳香化环化反应，以化学选择性方式将芳烃氧化为亲电子自由基中间体。该反应可以使用分子氧作为氧化剂，分子氧是地球上最丰富和普遍存在的氢受体。认为这些结果对于铁催化的发展是重要的知识。更多信息可以在内田达也等人的论文全文中找到。

更新日期：2020-03-09

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