Chiral Fused 1,2,3‐Triazoles: A Synthetic Overview,Asian Journal of Organic Chemistry

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Chiral Fused 1,2,3‐Triazoles: A Synthetic Overview
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-30 , DOI: 10.1002/ajoc.202000021
Manoj Dhameja ₁ , Hariom Kumar ₁ , Preeti Gupta ₁

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Triazoles have always occupied a pivotal position in the field of medicinal and pharmaceutical chemistry. Recently, the area of chiral fused triazoles has gained attention. The synthetic routes to access chiral fused triazole may involve either a natural or synthetic chiral starting material with a suitably functionalized azide and alkyne component or isomer resolution to achieve chirality. Asymmetric synthesis methods using chiral complexes and organocatalysis have also emerged for obtaining chiral fused triazoles. Herein, we have described an up‐to‐date overview of different synthetic protocols applied to construct chiral fused 1,2,3‐triazoles.

中文翻译：

手性熔融的1,2,3-三唑：合成概述

三唑在药物和药物化学领域一直占据着举足轻重的地位。近来，手性稠合三唑的领域引起了关注。获得手性稠合三唑的合成路线可能涉及具有适当官能化的叠氮化物和炔烃组分或异构体拆分以实现手性的天然或合成手性原料。还出现了使用手性配合物和有机催化的不对称合成方法，以获得手性稠合的三唑。本文中，我们描述了用于构建手性稠合的1,2,3-三唑的不同合成方案的最新概述。

更新日期：2020-03-30

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