Crosstalk between Endo/Exocytosis and Autophagy in Health and Disease.,Biotechnology Journal

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Crosstalk between Endo/Exocytosis and Autophagy in Health and Disease.
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-03-06 , DOI: 10.1002/biot.201900267
Margarita-Elena Papandreou _{1,

2} , Nektarios Tavernarakis _{1,

2}

Affiliation

Imbalance between the main intracellular degradative, trafficking and intercellular shuttling pathways has been implicated in disease pathogenesis. Autophagy controls degradation of cellular components, while vesicular trafficking permits transport of material in and out of the cell. Emerging evidence has uncovered the extensive interconnectivity between these pathways, which is crucial to maintain organismal homeostasis. Thus, therapeutic intervention and drug development strategies targeting these processes, particularly in neurodegeneration, should account for this broad crosstalk, to maximize effectiveness. Here, recent findings underlining the highly dynamic nature of the crosstalk between autophagy, endosomal transport, and secretion is reviewed. Synergy of autophagy and endosomes for degradation, as well as, competition of autophagy and secretion are discussed. Perturbation of this crosstalk triggers pathology especially neurodegeneration.

中文翻译：

健康和疾病中内吞/胞吐作用与自噬之间的串扰。

主要的细胞内降解途径，运输途径和细胞间穿梭途径之间的失衡与疾病的发病机理有关。自噬控制细胞成分的降解，而水泡运输允许物质进出细胞。新兴证据揭示了这些途径之间广泛的相互联系，这对于维持机体动态平衡至关重要。因此，针对这些过程的治疗干预和药物开发策略，尤其是在神经退行性疾病中，应考虑到这种广泛的相互影响，以最大程度地提高有效性。在这里，最近的发现强调了自噬，内体运输和分泌之间的串扰的高度动态性质。自噬与内体在降解中的协同作用，以及讨论了自噬和分泌的竞争。这种串扰的扰动会触发病理，尤其是神经变性。

更新日期：2020-03-06

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