Self-Assembling Proteins for Design of Anticancer Nanodrugs.,Chemistry - An Asian Journal

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Self-Assembling Proteins for Design of Anticancer Nanodrugs.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-03-31 , DOI: 10.1002/asia.202000135
Qianli Zou ₁ , Rui Chang ₁ , Xuehai Yan _{1,

2}

Affiliation

Inspired by the diverse protein-based structures and materials in organisms, proteins have been expected as promising biological components for constructing nanomaterials toward various applications. In numerous studies protein-based nanomaterials have been constructed with the merits of abundant bioactivity and good biocompatibility. However, self-assembly of proteins as a dominant approach in constructing anticancer nanodrugs has not been reviewed. Here, we provide a comprehensive account of the role of protein self-assembly in fabrication, regulation, and application of anticancer nanodrugs. The supramolecular strategies, building blocks, and molecular interactions of protein self-assembly as well as the properties, functions, and applications of the resulting nanodrugs are discussed. The applications in chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy, gene therapy, and combination therapy are included. Especially, manipulation of molecular interactions for realizing cancer-specific response and cancer theranostics are emphasized. By expounding the impact of molecular interactions on therapeutic activity, rational design of highly efficient protein-based nanodrugs for precision anticancer therapy can be envisioned. Also, the challenges and perspectives in constructing nanodrugs based on protein self-assembly are presented to advance clinical translation of protein-based nanodrugs and next-generation nanomedicine.

中文翻译：

用于抗癌纳米药物设计的自组装蛋白。

受生物体中多种基于蛋白质的结构和材料的启发，人们期望将蛋白质作为构建纳米材料以实现各种应用的有前途的生物成分。在许多研究中，已经构建了具有丰富生物活性和良好生物相容性的蛋白质基纳米材料。然而，蛋白质的自组装作为构建抗癌纳米药物的主要方法尚未得到审查。在这里，我们提供了蛋白质自组装在抗癌纳米药物的制备，调控和应用中的作用的综合说明。讨论了蛋白质自组装的超分子策略，构件和分子相互作用，以及所得纳米药物的性质，功能和应用。在化学疗法，放射疗法，包括光动力疗法，光热疗法，基因疗法和联合疗法。特别地，强调了用于实现癌症特异性反应和癌症治疗学的分子相互作用的操纵。通过阐述分子相互作用对治疗活性的影响，可以设想合理设计高效蛋白质基纳米药物用于精确的抗癌治疗。此外，提出了基于蛋白质自组装构建纳米药物的挑战和前景，以推进基于蛋白质的纳米药物和下一代纳米药物的临床翻译。通过阐述分子相互作用对治疗活性的影响，可以设想合理设计高效蛋白质基纳米药物用于精确的抗癌治疗。此外，提出了基于蛋白质自组装构建纳米药物的挑战和前景，以推进基于蛋白质的纳米药物和下一代纳米药物的临床翻译。通过阐明分子相互作用对治疗活性的影响，可以设想合理设计高效蛋白质基纳米药物用于精确的抗癌治疗。此外，提出了基于蛋白质自组装构建纳米药物的挑战和前景，以推进基于蛋白质的纳米药物和下一代纳米药物的临床翻译。

更新日期：2020-03-31

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