Development of a Pre-assembled Through-Bond Energy Transfer (TBET) Fluorescent Probe for Ratiometric Sensing of Anticancer Platinum(ll) Complexes.,Chemistry - An Asian Journal

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Development of a Pre-assembled Through-Bond Energy Transfer (TBET) Fluorescent Probe for Ratiometric Sensing of Anticancer Platinum(ll) Complexes.
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-03-30 , DOI: 10.1002/asia.202000157
Jun Xiang Ong ₁ , Wee Han Ang _{1,

2}

Affiliation

Fluorescence microscopy has emerged as an attractive technique to probe the intracellular processing of Pt-based anticancer compounds. Herein, we reported the first through-bond energy transfer (TBET) fluorescent probe NPR1 designed for sensitive detection and quantitation of PtII complexes. The novel TBET probe was successfully applied for ratiometric fluorescence imaging of anticancer PtII complexes such as cisplatin and JM118 in cells. Capitalizing on the ability of the probe to discriminate between PtII complexes and their PtIV derivatives, the probe was further applied to study the activation of PtIV prodrug complexes that are known to release active PtII species after intracellular reduction.

中文翻译：

预组装的全键能量转移（TBET）荧光探针的开发，用于比例检测抗癌铂（II）配合物。

荧光显微镜已成为一种有吸引力的技术，可用于探测基于Pt的抗癌化合物的细胞内加工。在这里，我们报道了第一个穿透键能量转移（TBET）荧光探针NPR1，设计用于PtII复合物的灵敏检测和定量。新型TBET探针已成功应用于细胞中抗癌PtII复合物（如顺铂和JM118）的比例荧光成像。利用探针区分PtII复合物及其PtIV衍生物的能力，将该探针进一步应用于研究已知在细胞内还原后释放出活性PtII物种的PtIV前药复合物的活化。

更新日期：2020-03-30

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