Long‐Range Fluorescence Propagation in Amyloidogenic β‐Sheet Films and Fibers,Advanced Optical Materials

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Long‐Range Fluorescence Propagation in Amyloidogenic β‐Sheet Films and Fibers
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2020-03-08 , DOI: 10.1002/adom.202000056
Boris Apter ₁ , Boris Fainberg ₂ , Amir Handelman ₁ , Igor Lapsker ₂ , Antonella Accardo ₃ , Carlo Diaferia ₃ , Giancarlo Morelli ₃ , Gil Rosenman ₄

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Newly developed PEGylated phenylalanine peptide derivatives (PEG‐F6) can self‐assemble to form hybrid multifunctional nanostructures of homogeneous thin polymer films and amyloid‐like fibers. Both adopt a β‐sheet architecture and acquire the unique properties of visible fluorescence (FL) found in β‐sheet amyloid fibrils also associated with neurodegenerative diseases. A new paradigm observed in PEG‐F6 amyloid‐like fibers is reported, which demonstrates unique FL and optical absorption (OA) covering the entire visible region. Despite the full overlap of the FL and OA spectra, the FL propagates for an unexpectedly large distance of hundreds of micrometers in these fibers. A new non‐waveguiding mechanism of FL light energy transfer in amyloidogenic fibers is proposed based on photon reabsorption theory. The discovered quasi‐white FL of PEG‐F6 β‐sheet amyloidogenic fibers and films consists of the newly observed green FL band along the known blue FL band. The proof‐of‐concept of long sub‐millimeter range FL propagation in specially grown amyloidogenic PEG‐F6 fiber‐photonic probes is reported. The results indicate that FL can propagate in nanoscale fibers and suggest biomedical applications for FL monitoring of disease‐related ultrathin amyloid fibrils and in integrated photonics for optogenetics.

中文翻译：

淀粉样蛋白形成的β片膜和纤维中的远距离荧光传播。

新开发的聚乙二醇化苯丙氨酸肽衍生物（PEG-F6）可以自组装形成均匀的聚合物薄膜和类淀粉样纤维的杂化多功能纳米结构。两者均采用β-折叠结构，并获得了与神经退行性疾病相关的β-折叠淀粉样原纤维中发现的可见荧光（FL）的独特特性。报道了在PEG-F6淀粉样纤维中观察到的新范式，它证明了独特的FL和光学吸收（OA）覆盖了整个可见区域。尽管FL和OA光谱完全重叠，但FL在这些光纤中的传播距离出乎意料地大了数百微米。基于光子重吸收理论，提出了一种新的非波导机制，用于淀粉样生成纤维中的FL光能传递。发现的PEG-F6β-折叠淀粉样变性纤维和薄膜的准白色FL由沿着已知的蓝色FL带的新观察到的绿色FL带组成。据报道，在特殊生长的淀粉样生成的PEG-F6光纤光子探针中，长至亚毫米范围的FL传播的概念证明。结果表明，FL可以在纳米级纤维中传播，并建议将其用于疾病相关超薄淀粉样蛋白原纤维的FL监测以及光子学的集成光子学中的生物医学应用。

更新日期：2020-03-08

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