Recent Highlights in Anti-infective Medicinal Chemistry from South Africa.,ChemMedChem

当前位置： X-MOL 学术 › ChemMedChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Recent Highlights in Anti-infective Medicinal Chemistry from South Africa.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-04-09 , DOI: 10.1002/cmdc.202000086
Clinton G L Veale ₁ , Ronel Müller ₁

Affiliation

Global advancements in biological technologies have vastly increased the variety of and accessibility to bioassay platforms, while simultaneously improving our understanding of druggable chemical space. In the South African context, this has resulted in a rapid expansion in the number of medicinal chemistry programmes currently operating, particularly on university campuses. Furthermore, the modern medicinal chemist has the advantage of being able to incorporate data from numerous related disciplines into the medicinal chemistry process, allowing for informed molecular design to play a far greater role than previously possible. Accordingly, this review focusses on recent highlights in drug-discovery programmes, in which South African medicinal chemistry groups have played a substantive role in the design and optimisation of biologically active compounds which contribute to the search for promising agents for infectious disease.

中文翻译：

南非抗感染药物化学的近期亮点。

生物技术的全球进步极大地增加了生物测定平台的种类和可访问性，同时又增进了我们对可药物化学空间的理解。在南非的情况下，这导致当前正在开展的药物化学计划的数量迅速增加，特别是在大学校园内。此外，现代药物化学家的优势在于能够将众多相关学科的数据整合到药物化学过程中，从而使知情的分子设计发挥比以往更大的作用。因此，本次审查着重于毒品发现计划中的最新亮点，

更新日期：2020-03-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11