Serrated polyps (SPs) and conventional adenomas represent 2 distinct groups of colorectal premalignancy. The influence of early life adiposity on risk of these precursors remains unclear. Within the Nurses' Health Study, the Nurses' Health Study 2, and the Health Professionals Follow‐up Study, we assessed body fatness during childhood using 9‐level somatotype and obtained weight and body mass index (BMI) in adulthood. We used multivariable‐adjusted logistic regression to examine the association of SPs and conventional adenomas with body fatness in early childhood (age 5), late childhood (age 10), early adulthood (age 18/21) and middle adulthood (baseline) and weight change during early‐to‐middle adulthood. During 18–20 years of follow‐up, we documented 8,697 SPs and 10,219 conventional adenomas in 132,514 women; 2,403 SPs and 4,495 conventional adenomas in 29,207 men. We found a modest positive association of adiposity in early and late childhood with risk of SPs and conventional adenomas, with odds ratios ranging from 1.12 to 1.18 for comparison of extreme somatotypes groups. The associations were attenuated after adjusting for adulthood BMI but remained significant for conventional adenomas. No association with early life body fatness was found in men. Adulthood body fatness and weight change during early‐to‐middle adulthood showed positive relationships with SPs and conventional adenomas in both women and men, with stronger associations observed for SPs (p _{heterogeneity} < 0.0001). Our findings indicated a potential role in development of colorectal cancer precursors of childhood body fatness in women, and early‐to‐middle adulthood weight gain and attained adiposity in both sexes.

中文翻译：

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整个生命过程中的身体肥胖以及锯齿状息肉和传统腺瘤的风险。

锯齿状息肉 (SP) 和常规腺瘤代表 2 组不同的结直肠癌前病变。早期肥胖对这些前体风险的影响尚不清楚。在护士健康研究、护士健康研究 2 和卫生专业人员随访研究中，我们使用 9 级体型评估了儿童时期的体脂率，并获得了成年期的体重和体重指数 (BMI)。我们使用多变量调整逻辑回归来检查 SP 和常规腺瘤与儿童早期（5 岁）、儿童晚期（10 岁）、成年早期（18/21 岁）和成年中期（基线）和体重的相关性成年早期到中期的变化。在 18-20 年的随访期间，我们记录了 132,514 名女性的 8,697 个 SP 和 10,219 个常规腺瘤；2,403 个 SP 和 4 个，29,207 名男性中有 495 例常规腺瘤。我们发现儿童早期和晚期肥胖与 SP 和常规腺瘤的风险之间存在适度的正相关，用于比较极端体型组的优势比范围为 1.12 至 1.18。在调整成年 BMI 后，这种关联减弱，但对传统腺瘤仍然显着。在男性中没有发现与早年身体肥胖有关。成年早期到中期的成年体脂肪和体重变化与女性和男性的 SP 和常规腺瘤呈正相关，对 SP 观察到更强的相关性。18 用于比较极端体型组。在调整成年 BMI 后，这种关联减弱，但对传统腺瘤仍然显着。在男性中没有发现与早年身体肥胖有关。成年早期到中期的成年体脂肪和体重变化与女性和男性的 SP 和常规腺瘤呈正相关，对 SP 观察到更强的相关性。18 用于比较极端体型组。在调整成年 BMI 后，这种关联减弱，但对传统腺瘤仍然显着。在男性中没有发现与早年身体肥胖有关。成年早期到中期的成年体脂肪和体重变化与女性和男性的 SP 和常规腺瘤呈正相关，对 SP 观察到更强的相关性。p_异质性 < 0.0001)。我们的研究结果表明，在女性儿童期肥胖、成年早期至中期体重增加和两性肥胖的结直肠癌前兆的发展中具有潜在作用。