Direct Stereoselective β‐Arylation of Enol Ethers by a Decarboxylative Heck‐Type Reaction,European Journal of Organic Chemistry

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Direct Stereoselective β‐Arylation of Enol Ethers by a Decarboxylative Heck‐Type Reaction
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-30 , DOI: 10.1002/ejoc.201901877
Mahmoud Hachem ₁ , Cédric Schneider ₁ , Christophe Hoarau ₁

Affiliation

Pd^II‐catalyzed decarboxylative Heck coupling of α‐alkoxyacrylates with (hetero)aryl carboxylic acids for the stereocontrolled production of (Z)‐β‐heteroarylated vinyl ethers is reported. This methodology offers a rational and step‐economical route to the family of attractive β‐arylated α‐alkoxy α,β‐unsaturated carboxylates, which is a relevant class of building blocks with different applications.

中文翻译：

脱羧Heck型反应对烯醇醚的直接立体选择性β-芳构化

报道了Pd ^II催化的α-烷氧基丙烯酸酯与（杂）芳基羧酸的Heck偶联，用于立体控制（Z）-β-杂芳基化乙烯基醚的生产。这种方法为吸引人的β-芳基化α-烷氧基α，β-不饱和羧酸盐家族提供了一条合理，分步经济的途径，这是一类具有不同应用的重要组成部分。

更新日期：2020-03-30

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