Deuterium Exchange between Arenes and Deuterated Solvents in the Absence of a Transition Metal: Synthesis of D‐Labeled Fluoroarenes,European Journal of Organic Chemistry

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Deuterium Exchange between Arenes and Deuterated Solvents in the Absence of a Transition Metal: Synthesis of D‐Labeled Fluoroarenes
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-09 , DOI: 10.1002/ejoc.202000284
Vanesa Salamanca ₁ , Ana C. Albéniz ₁

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Easy deuteration of fluoroarenes with good selectivity can be achieved by H/D exchange with inexpensive deuterated solvents in a sustainable way. Just alkali metal bases are enough to bring about the exchange, which does not require a transition metal. This exchange should be taken into account when using deuterium labeling for mechanistic studies under close related conditions.