Synthesis of Polysubstituted 2H‐Pyran‐2‐ones or Phenols via One‐Pot Reaction of (E)‐β‐Chlorovinyl Ketones and Electron‐Withdrawing Group Substituted Acetates or β‐Diketones,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of Polysubstituted 2H‐Pyran‐2‐ones or Phenols via One‐Pot Reaction of (E)‐β‐Chlorovinyl Ketones and Electron‐Withdrawing Group Substituted Acetates or β‐Diketones
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-24 , DOI: 10.1002/ejoc.202000199
Youchi Zhang ₁ , Jingli Zhang ₁ , Ye Yuan ₂ , Liran Liu ₁ , Bifeng Chen ₁ , Taolei Sun ₁

Affiliation

This paper describes a facile one‐pot synthesis of highly functionalized 2H‐pyran‐2‐ones and a regiospecific construction of 3,5‐disubstituted phenols via base‐promoted annulation of readily available β‐chlorovinyl ketones with various active methylene compounds. The detailed experimental studies demonstrated that versatile electrophilic pathways of β‐chlorovinyl ketones could be observed by using different nucelophilic species.

中文翻译：

通过（E）-β-氯丁二酮和吸电子基团取代的乙酸酯或β-二酮的一锅反应合成多取代的2H-吡喃-2-酮或苯酚

本文描述了通过碱促进容易获得的β-氯乙烯基酮与各种活性亚甲基化合物的环化反应，轻松实现高功能化2 H-吡喃-2-酮的一锅合成，以及3,5-二取代苯酚的区域特异性结构。详细的实验研究表明，通过使用不同的亲核物种，可以观察到β-氯乙烯基酮的多种亲电途径。

更新日期：2020-03-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11