A tri-metallic palladium complex with breast cancer stem cell potency,Dalton Transactions

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A tri-metallic palladium complex with breast cancer stem cell potency
Dalton Transactions ( IF 3.5 ) Pub Date : 2020/03/09 , DOI: 10.1039/d0dt00006j
Arvin Eskandari _{1,

2,

3,

4} , Arunangshu Kundu _{5,

6,

7,

8} , Alice Johnson _{4,

9,

10,

11} , Sanjib Karmakar _{5,

6,

7,

8} , Sushobhan Ghosh _{5,

6,

7,

8} , Kogularamanan Suntharalingam _{4,

9,

10,

11}

Affiliation

A multi-nuclear, triangular-shaped palladium(II) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(II) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.

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