Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement,Nanoscale

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Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement
Nanoscale ( IF 5.8 ) Pub Date : 2020/03/09 , DOI: 10.1039/d0nr01138j
Mans Broekgaarden _{1,

2,

3,

4,

5} , Anne-Laure Bulin _{2,

6,

7,

8,

9} , Estelle Porret _{1,

2,

3,

4,

5} , Benjamin Musnier _{1,

2,

3,

4,

5} , Benoit Chovelon _{2,

9,

10,

11,

12} , Corinne Ravelet _{2,

9,

10,

11} , Lucie Sancey _{1,

2,

3,

4,

5} , Hélène Elleaume _{2,

6,

7,

8,

9} , Pierre Hainaut _{1,

2,

3,

4,

5} , Jean-Luc Coll _{1,

2,

3,

4,

5} , Xavier Le Guével _{1,

2,

3,

4,

5}

Affiliation

Ultra-small gold nanoclusters (AuNCs) are increasingly investigated for cancer imaging and radiotherapy enhancement. While fine-tuning the AuNC surface chemistry can optimize their pharmacokinetics, its effects on radiotherapy enhancement remain largely unexplored. This study demonstrates that optimizing the surface chemistry of AuNCs for increased tumor uptake can significantly affect its potential to augment radiotherapy outcomes.

中文翻译：

金纳米团与精氨酸的表面功能化：微肿瘤吸收与放射治疗增强之间的权衡。

越来越多地研究超小型金纳米团簇（AuNC）的癌症成像和放射疗法增强作用。尽管微调AuNC表面化学可以优化其药代动力学，但其对放疗增强的作用仍未得到充分探索。这项研究表明，优化AuNCs的表面化学以增加肿瘤吸收可以显着影响其增强放射治疗结果的潜力。

更新日期：2020-04-03

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