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Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury
National Science Review ( IF 16.3 ) Pub Date : 2020-03-09 , DOI: 10.1093/nsr/nwaa037 Yingxia Liu 1 , Cong Zhang 2 , Fengming Huang 3 , Yang Yang 1 , Fuxiang Wang 1 , Jing Yuan 1 , Zheng Zhang 1 , Yuhao Qin 3 , Xiaoyun Li 3 , Dandan Zhao 3 , Shunwang Li 3 , Shuguang Tan 4 , Zhaoqin Wang 1 , Jinxiu Li 1 , Chenguang Shen 1 , Jianming Li 1 , Ling Peng 1 , Weibo Wu 1 , Mengli Cao 1 , Li Xing 1 , Zhixiang Xu 1 , Li Chen 1 , Congzhao Zhou 2 , William J Liu 4 , Lei Liu 1 , Chengyu Jiang 3
National Science Review ( IF 16.3 ) Pub Date : 2020-03-09 , DOI: 10.1093/nsr/nwaa037 Yingxia Liu 1 , Cong Zhang 2 , Fengming Huang 3 , Yang Yang 1 , Fuxiang Wang 1 , Jing Yuan 1 , Zheng Zhang 1 , Yuhao Qin 3 , Xiaoyun Li 3 , Dandan Zhao 3 , Shunwang Li 3 , Shuguang Tan 4 , Zhaoqin Wang 1 , Jinxiu Li 1 , Chenguang Shen 1 , Jianming Li 1 , Ling Peng 1 , Weibo Wu 1 , Mengli Cao 1 , Li Xing 1 , Zhixiang Xu 1 , Li Chen 1 , Congzhao Zhou 2 , William J Liu 4 , Lei Liu 1 , Chengyu Jiang 3
Affiliation
A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with 2019-nCoV infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-nCoV, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-nCoV-infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-α2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-γ, IL-1α, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of 2019-nCoV infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-nCoV infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.
更新日期：2020-03-09
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