The rodent retrosplenial cortex (RSC) functions as an integrative hub for sensory and motor signals, serving roles in both navigation and memory. While RSC is reciprocally connected with the sensory cortex, the form in which sensory information is represented in the RSC and how it interacts with motor feedback is unclear and likely to be critical to computations involved in navigation such as path integration. Here, we used 2-photon cellular imaging of neural activity of putative excitatory (CaMKII expressing) and inhibitory (parvalbumin expressing) neurons to measure visual and locomotion evoked activity in RSC and compare it to primary visual cortex (V1). We observed stimulus position and orientation tuning, and a retinotopic organization. Locomotion modulation of activity of single neurons, both in darkness and light, was more pronounced in RSC than V1, and while locomotion modulation was strongest in RSC parvalbumin-positive neurons, visual-locomotion integration was found to be more supralinear in CaMKII neurons. Longitudinal measurements showed that response properties were stably maintained over many weeks. These data provide evidence for stable representations of visual cues in RSC that are spatially selective. These may provide sensory data to contribute to the formation of memories of spatial information.

中文翻译：

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小鼠脾后皮层中视觉线索的稳定编码。

啮齿动物的脾后皮层 (RSC) 作为感觉和运动信号的综合枢纽，在导航和记忆中发挥作用。虽然 RSC 与感觉皮层相互连接，但感觉信息在 RSC 中表示的形式以及它如何与运动反馈相互作用尚不清楚，并且可能对路径整合等导航中涉及的计算至关重要。在这里，我们使用推定的兴奋性（表达 CaMKII）和抑制性（表达小清蛋白）神经元的神经活动的 2 光子细胞成像来测量 RSC 中的视觉和运动诱发活动，并将其与初级视觉皮层 (V1) 进行比较。我们观察到刺激位置和方向调整，以及视网膜组织。单个神经元活动的运动调节，在黑暗和光明中，在 RSC 中比 V1 更明显，虽然 RSC 小清蛋白阳性神经元的运动调节最强，但发现视觉运动整合在 CaMKII 神经元中更加超线性。纵向测量表明，响应特性在数周内稳定保持。这些数据为 RSC 中具有空间选择性的视觉线索的稳定表示提供了证据。这些可以提供感官数据，以有助于形成空间信息的记忆。这些数据为 RSC 中具有空间选择性的视觉线索的稳定表示提供了证据。这些可以提供感官数据，以有助于形成空间信息的记忆。这些数据为 RSC 中具有空间选择性的视觉线索的稳定表示提供了证据。这些可以提供感官数据，以有助于形成空间信息的记忆。