Blinded randomized crossover trial: Skin-to-skin care vs. sucrose for preterm neonatal pain.,Journal of Perinatology

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Blinded randomized crossover trial: Skin-to-skin care vs. sucrose for preterm neonatal pain.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-03-09 , DOI: 10.1038/s41372-020-0638-9
Somashekhar Nimbalkar ₁ , Vivek V Shukla _{1,

2} , Vishwa Chauhan ₁ , Ajay Phatak ₁ , Dipen Patel ₁ , Apurva Chapla ₁ , Archana Nimbalkar ₁

Affiliation

Objective

To compare skin-to-skin care (SSC) and oral sucrose for preterm neonatal pain control.

Methods

Preterm neonates (28–36 weeks gestation) requiring heel-stick were eligible. In group-A, SSC was given 15-min before first heel-stick, and sucrose was given 2-min before second heel-stick. In group-B, the sequence was reversed. Blinded premature infant pain profile (PIPP) score assessment was done at 0, 1, and 5-min of heel-stick by two assessors.

Results

A hundred neonates were enrolled. The inter-rater agreement for the PIPP score was good. The behavior state component was significantly lower in the sucrose group at all assessment points. The mean (SD) difference between 1-min and 0 min was similar [SSC 3.58(3.16) vs. sucrose 4.09(3.82), p = 0.24] between groups. The PIPP score attained baseline values at 5-min in both groups.

Conclusion

Albeit sucrose indicated instantaneous action, SSC and sucrose have comparable clinical efficacy for preterm neonatal pain control. Multisensory stimulation with SSC may result in a higher behavioral state component of the PIPP score.

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