Three-dimensional genome: developmental technologies and applications in precision medicine.,Journal of Human Genetics

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Three-dimensional genome: developmental technologies and applications in precision medicine.
Journal of Human Genetics ( IF 2.6 ) Pub Date : 2020-03-09 , DOI: 10.1038/s10038-020-0737-7
Yingqi Li ₁ , Tao Tao ₂ , Likun Du ₃ , Xiao Zhu ₁

Affiliation

In the 20th century, our familiar structure of DNA was the double helix. Due to technical limitations, we do not have a good way to understand the finer structure of the genome, let alone its transcriptional regulation. Until the advent of 3C technologies, we were no longer blind to this one. Three-dimensional (3D) genomics is a new subject, which mainly studies the 3D structure and transcriptional regulation of eukaryotic genomes. Now, this field mainly has Hi-C series and CHIA-PET series technologies. Through 3D genomics, we can understand the basic structure of DNA, understand the growth and development of organisms and the occurrence of diseases, so as to promote human medical and health undertakings. The review introduces the main research techniques of 3D genomics and their characteristics, the latest development of 3D genome structure, the relationship between diseases and 3D genome structure, the applications of 3D genome in precision medicine, and the development of the 4D nucleome project.

中文翻译：

三维基因组：精密医学的发展技术和应用。

在20世纪，我们熟悉的DNA结构是双螺旋。由于技术限制，我们没有一个很好的方法来了解基因组的精细结构，更不用说其转录调控了。在3C技术问世之前，我们不再对这一技术视而不见。三维（3D）基因组学是一门新兴的学科，主要研究真核生物基因组的3D结构和转录调控。现在，该领域主要具有Hi-C系列和CHIA-PET系列技术。通过3D基因组学，我们可以了解DNA的基本结构，了解生物的生长发育和疾病的发生，从而促进人类的医疗卫生事业。综述介绍了3D基因组学的主要研究技术及其特点，3D基因组结构的最新发展，

更新日期：2020-04-24

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