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A modern review of penile traction monotherapy and combination therapy for the treatment of peyronie’s disease
International Journal of Impotence Research ( IF 2.8 ) Pub Date : 2020-03-09 , DOI: 10.1038/s41443-020-0247-3
Raevti Bole 1 , Lindsay White 1 , Niki Parikh 1 , Sevann Helo 1 , Tobias Kohler 1 , Matthew Ziegelmann 1
Affiliation  

Peyronie’s disease (PD)-related penile deformity is managed with multiple treatment modalities including oral medications, intralesional injections, and surgery. Penile traction therapy (PTT) is one such modality with purported benefits, albeit with notable differences in the characteristics of available traction devices and published study protocols. We provide a comprehensive review of the available data supporting PTT for PD treatment. We performed a rigorous database search to identify all studies pertaining to PTT for the treatment of PD through November 2019. Seventeen trials explored use of PTT as monotherapy or in combination with surgical or nonsurgical treatment, using over five different commercially available devices. All devices were well tolerated, although compliance and daily duration of use were highly variable. PTT resulted in variable improvements in stretched penile length and penile curvature, depending on study protocol, patient population, and device. PTT appears to be a safe and well-tolerated treatment for PD as monotherapy or in combination with other nonsurgical and surgical treatments, and for men in both the acute and chronic phases. Further studies are needed to compare available devices, evaluate device characteristics associated with treatment success, differentiate outcomes in acute vs. chronic PD populations, and determine the optimal duration of use.



中文翻译:

阴茎牵引单药联合联合治疗佩罗尼病的现代综述

佩罗尼氏病 (PD) 相关的阴茎畸形通过多种治疗方式进行管理,包括口服药物、病灶内注射和手术。阴茎牵引疗法 (PTT) 就是这样一种具有据称益处的方式,尽管在可用牵引装置的特性和已发表的研究方案方面存在显着差异。我们对支持 PTT 治疗 PD 的可用数据进行了全面审查。我们进行了严格的数据库搜索,以确定截至 2019 年 11 月与 PTT 治疗 PD 相关的所有研究。17 项试验探讨了使用超过五种不同的市售设备将 PTT 作为单一疗法或与手术或非手术治疗联合使用。尽管依从性和每日使用持续时间差异很大,但所有设备均具有良好的耐受性。根据研究方案、患者群体和设备,PTT 导致阴茎拉伸长度和阴茎曲率的不同改善。PTT 似乎是一种安全且耐受性良好的 PD 单药治疗或与其他非手术和手术治疗相结合的治疗方法,同时适用于急性期和慢性期的男性。需要进一步的研究来比较可用的设备,评估与治疗成功相关的设备特征,区分急性和慢性 PD 人群的结果,并确定最佳使用持续时间。对于处于急性期和慢性期的男性。需要进一步的研究来比较可用的设备,评估与治疗成功相关的设备特征,区分急性和慢性 PD 人群的结果,并确定最佳使用持续时间。对于处于急性期和慢性期的男性。需要进一步的研究来比较可用的设备,评估与治疗成功相关的设备特征,区分急性和慢性 PD 人群的结果,并确定最佳使用持续时间。

更新日期:2020-04-24
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